Preparation, Characterisation, Crystal Structure and Antibacterial Activity of two Bis-Schiff Bases Containing a Piperazine Ring-Reference-Cited by-同舟云学术

Preparation, Characterisation, Crystal Structure and Antibacterial Activity of two Bis-Schiff Bases Containing a Piperazine Ring

Published:2018-10 Issue:10 Volume:42 Page:512-514
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Xu Rui-bo¹²,Yang Xiao-tian²,Li Hai-nan²,Zhao Peng-cheng²,Li Jiao-jiao²,Zhao Yu-xia³

Affiliation:

1. Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Huaihai Institute of Technology, Lianyungang 222005, P.R. China

2. Pharmaceutical Engineering School, Huaihai Institute of Technology, 222005 Lianyungang, P.R. China

3. Nanotechnology and Health Research Institute School of Basic Medicine, Shanghai University of Medicine and Health Sciences, Shanghai 201318, P.R. China

Abstract

Two new bis-Schiff bases containing a piperazine ring, N,N‘-bis(4-chlorobenzylidene)- and N,N‘-bis(4-cyanobenzylidene)-1,4-bis(3-aminopropyl)piperazine, were prepared by the reaction of N,N‘-bis(3-aminopropyl)piperazine with 4-chloro- and 4-cyanobenzaldehyde, respectively. The dichloro compound was fully identified by X-ray crystallography and it exhibited good antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751918X15383854898654

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