A Convenient Synthesis of Gimeracil-Reference-Cited by-同舟云学术

A Convenient Synthesis of Gimeracil

Published:2018-01 Issue:1 Volume:42 Page:33-34
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Li Xiao-lin¹,Zhu Hao-ting¹,Zhan Li¹,Liu Ting¹,Cheng Guang²,Liu Ning²,Yu Shan-bao³,Li Hui³,Luo Yu¹,Yang Fan¹,Tang Jie¹

Affiliation:

1. Department of Chemistry, School of Chemistry and Molecular Engineering (Current address: Shanghai Engineering Research Centre of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering), East China Normal University, Shanghai, 200241, P.R. China

2. Nanjing Luye Pharmaceutical Co., Ltd., Nanjing 210061, P.R. China

3. PharmaBlock Sciences (Nanjing), Inc., Nanjing 210032, P.R. China

Abstract

A practical three-step synthetic approach to gimeracil in a 68% overall yield is described, using 2,4-dimethoxypyridine as the starting material with 3,5-dichloro-2,4-dimethoxypyridine and 3,5-dichloro-2,4-dihydroxypyridine as intermediates. The advantages of this procedure include short reaction steps, simple operation and good yield.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751918X15166150010920

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