Simultaneously Rapid Deprotection of 3-acyloxy groups and reduction of D-ring ketones (nitrile) of steroids using DIBAL-H/NiCl2-Reference-Cited by-同舟云学术

Simultaneously Rapid Deprotection of 3-acyloxy groups and reduction of D-ring ketones (nitrile) of steroids using DIBAL-H/NiCl2

Published:2011-05 Issue:5 Volume:35 Page:291-293
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Wang Xingbin¹,Liu Hui¹,Yan Peiyun¹,Liu Jinliang¹,Li Yan¹,Sun Qian¹,Wang Cunde¹

Affiliation:

1. School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China

Abstract

An efficient preparation of hydroxysteroids by a one-pot, simultaneously rapid deprotection of 3-acyloxy groups and reduction of D-ring ketones (nitrile) of steroids using DIBAL-H in the presence of NiCl2 (10 mol %) is described. The attractive features of this procedure for the preparation of the hydroxysteroid derivatives are the mild reaction conditions, short reaction time, excellent yields, clean reaction profiles, and an inexpensive catalyst system.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751911X13050949941793

Reference22 articles.

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