Utility of Cyano-N-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide in the Synthesis of Novel Heterocycles-Reference-Cited by-同舟云学术

Utility of Cyano-N-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide in the Synthesis of Novel Heterocycles

Published:2013-02 Issue:2 Volume:37 Page:80-85
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Mahmoud Mahmoud R.¹,El-Ziaty Ahmed K.¹,El-Azm Fatma S. M. Abu¹,Ismail Mahmoud F.¹,Shiba Sayed A.²

Affiliation:

1. Chemistry Department, Faculty of Science, Ain Shams University, 11566 Abbassia, Cairo, Egypt

2. Chemistry Department, Faculty of Science and Arts, Sajer Shaqra University, Saudia Arabia

Abstract

Cyano- N-(2-oxo-1,2-dihydroindol-3-ylidene)acetohydrazide was prepared by condensation of isatin with cyanoaceto-hydrazide in refluxing 1,4-dioxane. Subsequent reaction with a variety of electrophilic and nucleophilic reagents afforded novel heterocyclic compounds and spirooxoindoles. The IR, 1H NMR and mass spectra of all the synthesised compounds are discussed.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751912X13567100793191

Reference21 articles.

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4. An Investigation into the Cytotoxicity and Mode of Action of Some Novel N-Alkyl-Substituted Isatins

5. The chemistry of isatins: a review from 1975 to 1999

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