Efficient Ionic Liquid-Catalysed Synthesis and Antimicrobial Studies of 4,6-diaryl- and 4,5-fused pyrimidine-2-thiones

Author:

Gupta Richa1,Chaudhary Ram Pal1

Affiliation:

1. Department of Chemistry, Sant Longowal Institute of Engineering and Technology, Longowal (Sangrur) Punjab-148106, India

Abstract

One-pot three-component condensation of aromatic ketones (1-tetralones, acetophenones, indane-1,3-dione), substituted aromatic aldehydes and thiourea in the presence of N-methylpyridinium tosylate under solvent free conditions at 100–110 °C for 2–4 h afforded tetrahydrobenzo[ h]quinazoline-2-thiones, pyridimidine-2-thiones and indeno-pyrimidine-2-thiones in excellent yields. All synthesised thiones were screened for their antimicrobial activities.

Publisher

SAGE Publications

Subject

General Chemistry

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