Affiliation:
1. Department of Chemistry, Faculty of Science, Arak University, Arak 38156-879, Iran
Abstract
A series of novel bis-1,2,4-triazoles and bis-1,3,4-thiadiazoles bearing pyridine rings was synthesised, by multistep reaction sequences, in good to high yields. Reaction of pyridine-2,5-bis- and pyridine-2,6-bis-carbohydrazides with alkyl- or aryl-isothiocyanates gave the corresponding bis(thiosemicarbazide) derivatives, which could be cyclised under strongly basic conditions to give novel pyridine bis(1,2,4-triazole-3-thiols). However, under strongly acidic conditions the corresponding bis(2-amino-1,3,4-thiadiazoles) were obtained. The synthetic routes and spectroscopic characterisation of the new compounds are reported.
Cited by
6 articles.
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1. New Antibacterial 1,3,4‐Thiadiazole Derivatives With Pyridine Moiety;Chemistry & Biodiversity;2024-05-16
2. Synthesis and Optical Properties of New S-Derivatives of 5,5′-(1,4-Phenylene)bis(4H-1,2,4-triazole-3-thiol) and 5,5′,5″-(Benzene-1,3,5-triyl)tris(4H-1,2,4-triazole-3-thiol);Russian Journal of General Chemistry;2019-12
3. Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles;Journal of Biochemical and Molecular Toxicology;2017-11-13
4. Mono- and bis-dipicolinic acid heterocyclic derivatives – thiosemicarbazides, triazoles, oxadiazoles and thiazolidinones as antifungal and antioxidant agents;Heterocyclic Communications;2017-01-01
5. Electrochemical and Theoretical Evaluation of 5,5′-(Pyridine-2,6-diyl)bis(4-phenyl-4H-1,2,4-triazole-3-thiol) as a Novel Corrosion Inhibitor of Mild Steel in the Acidic Medium;International Journal of Electrochemical Science;2015-08