Kinetics of the Acetaminophen-Based Oscillatory Chemical Reaction with and without Ferroin as Catalyst: An Inorganic Prototype Model for Acetaminophen–Ethanol Syndrome

Abstract

This paper describes the nonlinear behaviour of the acetaminophen-based uncatalysed Belousov–Zhabotinsky oscillator and its dynamics in the presence of ferroin as catalyst. The role of free metal ions as catalysts was examined and the results compared with those of corresponding complexed catalysts. Free metal ions were found to be sluggish with respect to the evolution of the oscillatory regime as compared to complexed ones. The effect was monitored of change of the ligand moiety of the catalyst complex on the oscillatory parameters. Since ethanol potentiates the hepatotoxicity caused by acetaminophen in vivo, it is thought to understand this interaction by virtue of causing perturbation of the acetaminophen-based oscillator with different concentrations of ethanol with and without ferroin as catalyst. Another dimension to the ethanol effect was examined by perturbation of the system with ethanol at different stages of the reaction so as to get an idea as to whether it is acetaminophen or some reactive intermediate generated in the reaction system which reacts with ethanol. Further, the ferroin-catalysed oscillator is taken as a prototype inorganic model of the acetaminophen–ethanol syndrome, as ferroin and hypobromous acid (HOBr) act as inorganic replacements for cytochrome P450 and nicotinamide adenine dinucleotide phosphate (NADPH) in alcohol metabolism.