Affiliation:
1. Chemistry Department, Faculty of Science, Assiut University, Assiut 71516, Egypt
Abstract
1-Amino-5-morpholino-6,7,8,9-tetrahydrothieno[2,3- c]isoquinoline-2-carbonitrile has been converted to the chloro-acetylamino derivative which was subjected to nucleophilic substitution reactions with different amines. Reaction of 1-amino-5-morpholino-6,7,8,9-tetrahydrothieno[2,3- c]isoquinoline- 2-carbonitrile with triethyl orthoformate followed by cyclisation with hydrazine yielded an aminoiminopyrimidine derivative. The latter was used as a starting material for the synthesis of a variety of fused heterocyclic compounds which include triazolopyrimidothienotetrahydroiso-quinolines.
Cited by
9 articles.
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1. Efficient Synthesis, Reactions and Anti-Inflammatory Evaluation of Novel Cyclopenta[d]thieno[2,3-b]pyridines and Their Related Heterocycles;Russian Journal of Bioorganic Chemistry;2022-12
2. Synthesis, characterization and antimicrobial investigation of new piperidinyl tetrahydrothieno[2,3-c]isoquinolines;Arabian Journal of Chemistry;2021-09
3. Synthesis, Reactions, and Antimicrobial Activity of Novel Heterocyclic Compounds Containing Cyclopenta[d]thieno[2,3-b]pyridine Moiety and Related Fused Heterocycles;Russian Journal of Bioorganic Chemistry;2020-01
4. Synthesis and Antimicrobial Activity of Novel Piperidinyl Tetrahydrothieno[2,3-c]isoquinolines and Related Heterocycles;ACS Omega;2019-12-30
5. Substituted N-(thieno[2,3-b]pyridine-3-yl)acetamides: synthesis, reactions, and biological activity;Monatshefte für Chemie - Chemical Monthly;2019-10-14