Affiliation:
1. Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, 91775-1436 Mashhad, Iran
2. Department of Pharmacology and Pharmacological Research Centre of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3. Department of Chemistry, Payam Noor University, Mashhad, Iran
Abstract
The synthesis of new derivatives of 3-phenyl-1,5-dimethyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazines 5a–e and 7a–e is described through heterocyclisation of hydrazino derivative (3) with aromatic aldehydes or carbon disulfide and alkyl halides. [(1,5-Dimethyl-3-phenyl-1H-[1,2,4]triazolo[4′,3′:1,2]pyrimido[4,5-e][1,3,4]oxadiazin-7-yl) sulfanyl]methyl cyanide was singled out to be tested on different cancer cell lines including HeLa, MCF-7, and HepG2. Malignant cells were cultured in DMEM medium and incubated with different concentrations of the titled compounds. Cell viability was quantified by MTT assay.
Cited by
15 articles.
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