One-Step Synthesis of Chromene-3-Carboxamide, Bischromene, Chromeno[3,4-c]Pyridine and Bischromeno[3,4-c]Pyridine Derivatives for Antimicrobial Evaluation

Abstract

Cyanoacetamide derivatives were reacted with salicylaldehyde under different conditions afforded chromenes and coumarin derivatives respectively. A number of chromeno[3,4- c]pyridine derivatives were prepared from the reaction of N-cyclohexyl-2-imino-2H-chromene-3-carboxamide with malononitrile and/or cynaothiocatemaide. Bischromeno[3,4- c]pyridine derivatives were prepared from the reaction of N,N’-(ethane-1,2-diyl)bis(2-imino-2H-chromene-3-carboxamide) with malononitrile and/or N-alkyl-2-cyanoacetamide derivative with 2-iminochroemen derivative, respectively. Some of these compounds were screened for their antimicrobial activities.