Study on the Structure-Activity Relations of Pleuromutilin Derivatives with an Aromatic Amide and a Thioether Group in the C14 side Chain-Reference-Cited by-同舟云学术

Study on the Structure-Activity Relations of Pleuromutilin Derivatives with an Aromatic Amide and a Thioether Group in the C14 side Chain

Published:2010-06 Issue:6 Volume:34 Page:354-357
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Xu Ke-ping¹,Zhang Yuan-yuan²,Luo Juan¹,Chen Shan-li¹,Wang Yu-liang¹

Affiliation:

1. College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China

2. Department of Chemical Engineering, Sichuan University, Chengdu 610065, P. R. China

Abstract

Nine novel pleuromutilin derivatives having benzamide substituents have been synthesised permitting structure-activity relations of pleuromutilin derivatives with aromatic amide and thioether groups in the C14 side chain to be studied. The results showed that the heterocyclic carboxamide group was necessary to enhance bio-activities.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823410X12744531851242

Reference16 articles.

1. Antibiotic Substances From Basidiomycetes: VIII. Pleurotus Multilus (Fr.) Sacc. and Pleurotus Passeckerianus Pilat

2. Antimicrobial Activities of 81.723 hfu, a New Pleuromutilin Derivative

3. Studies on pleuromutilin and some of its derivatives.

4. New pleuromutilin derivatives with enhanced antimicrobial activity. I. Synthesis.

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