1. From the Department of Metabolic and Endocrine Disease (WIMV and BvdS) and the Complex Genetics Section, DBG-Department of Medical Genetics (WIMV, CW, and BvdS), University Medical Center Utrecht, Utrecht, Netherlands, and the Department of Genetics (CW) and the Department of Pathology and Laboratory Medicine (BvdS), University Medical Center Groningen, University of Groningen, Groningen, Netherl