Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions

Author:

de Vries Paul S1,Brown Michael R1,Bentley Amy R2,Sung Yun J3,Winkler Thomas W4,Ntalla Ioanna5,Schwander Karen3,Kraja Aldi T6,Guo Xiuqing7,Franceschini Nora8,Cheng Ching-Yu91011,Sim Xueling12,Vojinovic Dina13,Huffman Jennifer E14,Musani Solomon K15,Li Changwei16,Feitosa Mary F6,Richard Melissa A17,Noordam Raymond18,Aschard Hugues1920,Bartz Traci M21,Bielak Lawrence F22,Deng Xuan23,Dorajoo Rajkumar24,Lohman Kurt K25,Manning Alisa K2627,Rankinen Tuomo28,Smith Albert V2930,Tajuddin Salman M31,Evangelou Evangelos3233,Graff Mariaelisa8,Alver Maris34,Boissel Mathilde35,Chai Jin Fang12,Chen Xu36,Divers Jasmin37,Gandin Ilaria38,Gao Chuan39,Goel Anuj4041,Hagemeijer Yanick42,Harris Sarah E4344,Hartwig Fernando P4546,He Meian47,Horimoto Andrea R V R48,Hsu Fang-Chi37,Jackson Anne U49,Kasturiratne Anuradhani50,Komulainen Pirjo51,Kühnel Brigitte5253,Laguzzi Federica54,Lee Joseph H55,Luan Jian'an56,Lyytikäinen Leo-Pekka5758,Matoba Nana59,Nolte Ilja M60,Pietzner Maik6162,Riaz Muhammad6364,Said M Abdullah42,Scott Robert A56,Sofer Tamar2765,Stančáková Alena66,Takeuchi Fumihiko67ORCID,Tayo Bamidele O68,van der Most Peter J60,Varga Tibor V69,Wang Yajuan70,Ware Erin B71,Wen Wanqing72,Yanek Lisa R73,Zhang Weihua3274,Zhao Jing Hua56ORCID,Afaq Saima32,Amin Najaf13,Amini Marzyeh60,Arking Dan E75,Aung Tin91176,Ballantyne Christie7778,Boerwinkle Eric7980,Broeckel Ulrich81,Campbell Archie82,Canouil Mickaël35,Charumathi Sabanayagam910,Chen Yii-Der Ida7,Connell John M83,de Faire Ulf54,de las Fuentes Lisa384,de Mutsert Renée85,de Silva H Janaka86,Ding Jingzhong87,Dominiczak Anna F88,Duan Qing89,Eaton Charles B90,Eppinga Ruben N42,Faul Jessica D71,Fisher Virginia23,Forrester Terrence91,Franco Oscar H1392,Friedlander Yechiel93,Ghanbari Mohsen1394,Giulianini Franco,Grabe Hans J95,Grove Megan L1,Gu C Charles3,Harris Tamara B96,Heikkinen Sami6697,Heng Chew-Kiat9899,Hirata Makoto100,Hixson James E79,Howard Barbara V101102,Ikram M Arfan13103104,Jacobs David R105,Johnson Craig106,Jonas Jost Bruno107108,Kammerer Candace M109,Katsuya Tomohiro110111,Khor Chiea Chuen24112,Kilpeläinen Tuomas O113114,Koh Woon-Puay12115,Koistinen Heikki A116117118,Kolcic Ivana,Kooperberg Charles119,Krieger Jose E48,Kritchevsky Steve B120,Kubo Michiaki121,Kuusisto Johanna66,Lakka Timo A5197122,Langefeld Carl D37,Langenberg Claudia56,Launer Lenore J96,Lehne Benjamin32,Lemaitre Rozenn N123,Li Yize3,Liang Jingjing70,Liu Jianjun24124,Liu Kiang125,Loh Marie32126,Louie Tin127,Mägi Reedik34,Manichaikul Ani W128,McKenzie Colin A91,Meitinger Thomas129130,Metspalu Andres34,Milaneschi Yuri131,Milani Lili34,Mohlke Karen L89,Mosley Thomas H132,Mukamal Kenneth J133,Nalls Mike A134135,Nauck Matthias6162,Nelson Christopher P6364,Sotoodehnia Nona136,O'Connell Jeff R137138,Palmer Nicholette D139,Pazoki Raha32,Pedersen Nancy L36,Peters Annette5362,Peyser Patricia A22,Polasek Ozren140141142,Poulter Neil143,Raffel Leslie J144,Raitakari Olli T145146,Reiner Alex P119,Rice Treva K3,Rich Stephen S147,Robino Antonietta148,Robinson Jennifer G149,Rose Lynda M150,Rudan Igor151,Schmidt Carsten O152,Schreiner Pamela J105,Scott William R32153,Sever Peter153,Shi Yuan9,Sidney Stephen154,Sims Mario15,Smith Blair H155,Smith Jennifer A2271,Snieder Harold60,Starr John M43156,Strauch Konstantin157158,Tan Nicholas911,Taylor Kent D7,Teo Yik Ying1224159160161,Tham Yih Chung9,Uitterlinden André G13162,van Heemst Diana18,Vuckovic Dragana38,Waldenberger Melanie5253,Wang Lihua6,Wang Yujie8,Wang Zhe1,Wei Wen Bin163,Williams Christine6,Wilson Gregory164,Wojczynski Mary K6,Yao Jie7,Yu Bing1,Yu Caizheng47,Yuan Jian-Min165166,Zhao Wei22,Zonderman Alan B167,Becker Diane M73,Boehnke Michael49,Bowden Donald W139,Chambers John C3274168169170,Deary Ian J43171,Esko Tõnu34172,Farrall Martin4041,Franks Paul W69173174175,Freedman Barry I176,Froguel Philippe35177,Gasparini Paolo38148,Gieger Christian52178,Horta Bernardo L45,Kamatani Yoichiro59,Kato Norihiro67,Kooner Jaspal S74153169179,Laakso Markku66,Leander Karin54,Lehtimäki Terho5758,Magnusson Patrik K E36,Penninx Brenda131,Pereira Alexandre C48,Rauramaa Rainer51,Samani Nilesh J6364,Scott James153,Shu Xiao-Ou72,van der Harst Pim42180,Wagenknecht Lynne E181,Wang Ya Xing182,Wareham Nicholas J56,Watkins Hugh4041,Weir David R71,Wickremasinghe Ananda R50,Zheng Wei72,Elliott Paul32170179183184,North Kari E8185,Bouchard Claude28,Evans Michele K31,Gudnason Vilmundur2930,Liu Ching-Ti23,Liu Yongmei186,Psaty Bruce M187188,Ridker Paul M150189,van Dam Rob M12173124,Kardia Sharon L R22,Zhu Xiaofeng70,Rotimi Charles N2,Mook-Kanamori Dennis O85190,Fornage Myriam117,Kelly Tanika N191,Fox Ervin R192,Hayward Caroline14,van Duijn Cornelia M13,Tai E Shyong12115124,Wong Tien Yin91176,Liu Jingmin193,Rotter Jerome I7,Gauderman W James194,Province Michael A6,Munroe Patricia B5195,Rice Kenneth127,Chasman Daniel I150189,Cupples L Adrienne23196,Rao Dabeeru C3,Morrison Alanna C1, ,

Affiliation:

1. Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, Texas

2. Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland

3. Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri

4. Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany

5. Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom

6. Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, Missouri

7. Genomic Outcomes, Pediatrics, Institute for Translational Genomics and Population Sciences, LA BioMed at Harbor-UCLA Medical Center, Torrance, California

8. Epidemiology, University of North Carolina Gilling School of Global Public Health, Chapel Hill, North Carolina

9. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

10. Centre for Quantitative Medicine, Academic Medicine Research Institute, Ophthalmology & Visual Sciences Academic Clinical Program

11. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

12. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore

13. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands

14. Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

15. Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi

16. Epidemiology and Biostatistics, University of Georgia at Athens College of Public Health, Athens, Georgia

17. Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, Texas

18. Internal Medicine, Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands

19. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts

20. Centre de Bioinformatique, Biostatistique et Biologie Intégrative

21. Cardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, Washington

22. Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan

23. Biostatistics, Boston University School of Public Health, Boston, Massachusetts

24. Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore

25. Public Health Sciences, Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, North Carolina

26. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts

27. Department of Medicine, Harvard Medical School, Boston, Massachusetts

28. Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana

29. Icelandic Heart Association, Kopavogur, Iceland

30. Faculty of Medicine, University of Iceland, Reykjavik, Iceland

31. Health Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

32. Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

33. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece

34. Estonian Genome Center, University of Tartu, Tartu, Estonia

35. CNRS UMR 8199, European Genomic Institute for Diabetes

36. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Stockholm, Sweden

37. Biostatistical Sciences, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina

38. Department of Medical Sciences, University of Trieste, Trieste, Italy

39. Molecular Genetics and Genomics Program, Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, North Carolina

40. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire, United Kingdom

41. Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, United Kingdom

42. Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

43. Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom

44. Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh, United Kingdom

45. Postgraduate Programme in Epidemiology, Federal University of Pelotas, Pelotas, RS, Brazil

46. Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom

47. Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

48. Laboratory of Genetics and Molecular Cardiology, Heart Institute

49. Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan

50. Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

51. Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland

52. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

53. Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

54. Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

55. Sergievsky Center and Taub Institute, Columbia University Medical Center, New York, New York

56. MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom

57. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland

58. Department of Clinical Chemistry, Finnish Cardiovascular Research Center – Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

59. Laboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

60. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

61. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

62. DZHK

63. Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

64. NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom

65. Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, Massachusetts

66. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland

67. Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

68. Department of Public Health Sciences, Loyola University Chicago, Maywood, Illinois

69. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Skåne University Hospital, Malmö, Sweden

70. Department of Population and Quantitative Health and Sciences, Case Western Reserve University, Cleveland, Ohio

71. Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan

72. Division of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

73. Division of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

74. Department of Cardiology, Ealing Hospital, Middlesex, United Kingdom

75. McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland

76. Ophthalmology & Visual Sciences Academic Clinical Program

77. Section of Cardiovascular Research, Baylor College of Medicine, Houston, Texas

78. Houston Methodist Debakey Heart and Vascular Center, Houston, Texas

79. Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, Texas

80. Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas

81. Section of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin

82. Centre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom

83. Ninewells Hospital & Medical School, University of Dundee, Dundee, Scotland, United Kingdom

84. Cardiovascular Division, Department of Medicine, Washington University, St. Louis, Missouri

85. Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands

86. Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka

87. Center on Diabetes, Obesity, and Metabolism, Gerontology and Geriatric Medicine, Wake Forest University Health Sciences, Winston-Salem, North Carolina

88. Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom

89. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina

90. Department of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, Rhode Island

91. Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica

92. Institute of Social and Preventive Medicine

93. Braun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

94. Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

95. Department Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany

96. Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland

97. Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio Campus, Finland

98. Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

99. Khoo Teck Puat – National University Children's Medical Institute, National University Health System, Singapore, Singapore

100. Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku, Japan

101. MedStar Health Research Institute, Hyattsville, Maryland

102. Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, District of Columbia

103. Department of Radiology and Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

104. Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands

105. Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota

106. Collaborative Health Studies Coordinating Center, University of Washington, Seattle, Washington

107. Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany

108. Beijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China

109. Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

110. Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan

111. Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan

112. Department of Biochemistry, National University of Singapore, Singapore, Singapore

113. Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

114. Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, New York

115. Duke-NUS Medical School, Singapore, Singapore

116. Department of Health, National Institute for Health and Welfare, Helsinki, Finland

117. Department of Medicine and Abdominal Center, Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

118. Minerva Foundation Institute for Medical Research, Helsinki, Finland

119. Fred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, Washington

120. Sticht Center for Health Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

121. Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

122. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland

123. Cardiovascular Health Research Unit, Medicine, University of Washington, Seattle, Washington

124. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

125. Epidemiology, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois

126. Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore

127. Department of Biostatistics, University of Washington, Seattle, Washington

128. Biostatistics Section, Center for Public Health Genomics, University of Virginia, School of Medicine, West Complex, Charlottesville, Virginia

129. Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

130. Institute of Human Genetics, Technische Universität München, Munich, Germany

131. Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, The Netherlands

132. Geriatrics, Medicine, University of Mississippi Medical Center, Jackson, Mississippi

133. General Medicine & Primary Care, Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts

134. Data Tecnica International, Glen Echo, Maryland

135. Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland

136. Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, Washington

137. Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland

138. Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, Maryland

139. Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina

140. Department of Public Health, Department of Medicine, University of Split, Split, Croatia

141. Psychiatric Hospital “Sveti Ivan”, Zagreb, Croatia

142. Gen-info Ltd, Zagreb, Croatia

143. School of Public Health, Imperial College London, London, United Kingdom

144. Division of Genetic and Genomic Medicine, Department of Pediatrics, University of California, Irvine, California

145. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

146. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

147. Center for Public Health Genomics, University of Virginia, School of Medicine, West Complex, Charlottesville, Virginia

148. Institute for Maternal and Child Health – IRCCS “Burlo Garofolo”, Trieste, Italy

149. Department of Epidemiology and Medicine, University of Iowa, Iowa City, Iowa

150. Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts

151. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, United Kingdom

152. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

153. National Heart and Lung Institute, Imperial College London, London, United Kingdom

154. Division of Research, Kaiser Permanente of Northern California, Oakland, California

155. Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom

156. Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh, United Kingdom

157. Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany

158. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany

159. Life Sciences Institute, National University of Singapore, Singapore, Singapore

160. NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore, Singapore

161. Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore

162. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands

163. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China

164. Jackson Heart Study, School of Public Health, Jackson State University, Jackson, Mississippi

165. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

166. Division of Cancer Control and Population Sciences, UPMC Hillman Cancer, University of Pittsburgh, Pittsburgh, Pennsylvania

167. Behavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, Maryland

168. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

169. Imperial College Healthcare NHS Trust, London, United Kingdom

170. MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom

171. Psychology, The University of Edinburgh, Edinburgh, United Kingdom

172. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, Massachusetts

173. Department of Nutrition, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts

174. Department of Public Health & Clinical Medicine, Umeå University, Umeå, Västerbotten, Sweden

175. OCDEM, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom

176. Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina

177. Department of Genomics of Common Disease, Imperial College London, London, United Kingdom

178. German Center for Diabetes Research

179. NIHR Imperial College Biomedical Research Centre, Imperial College London, London, United Kingdom

180. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

181. Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina

182. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China

183. Health Data Research UK

184. UK Dementia Research Institute

185. Carolina Center of Genome Sciences, University of North Carolina, Chapel Hill, North Carolina

186. Public Health Sciences, Epidemiology and Prevention, Wake Forest University Health Sciences, Winston-Salem, North Carolina

187. Cardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, Washington

188. Kaiser Permanente Washington, Health Research Institute, Seattle, Washington

189. Harvard Medical School, Boston, Massachusetts

190. Public Health and Primary Care, Leiden University Medical Center, Leiden, Leiden

191. Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana

192. Cardiology, Medicine, University of Mississippi Medical Center, Jackson, Mississippi

193. WHI CCC, Fred Hutchinson Cancer Research Center, Seattle, Washington

194. Biostatistics, Preventive Medicine, University of Southern California, Los Angeles, California

195. NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London, United Kingdom

196. NHLBI Framingham Heart Study, Framingham, Massachusetts

Funder

National Heart, Lung, and Blood Institute

US National Institutes of Health

NHLBI

American Heart Association

NIH

National Institute on Aging

Intramural Research Program

National Eye Institute

National Institute on Deafness and Other Communication Disorders

National Human Genome Research Institute

Fundação de Amparo a Pesquisa do Estado de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Hospital Samaritano Society

National Institute of Neurological Disorders and Stroke

NIA

National Center for Advancing Translational Sciences

Clinical and Translational Science Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Diabetes Research Center

University of Alabama at Birmingham

Northwestern University

University of Minnesota

Kaiser Foundation Research Institute

Johns Hopkins School of Medicine

Intramural Research Program of the NIH

NHLBI Candidate-Gene Association Resource

National Human Genome Research Institute’s

Medical Research Council

Croatian Ministry of Science

Education and Sports

European Commission

Sixth Framework Programme

Croatian Science Foundation

Wellcome Trust

Seventh Framework Programme

Fifth Framework Programme

European Network for Genetic and Genomic Epidemiology (ENGAGE) Consortium

Centre for Medical Systems Biology

Netherlands Organisation for Scientific Research

Russian Foundation for Basic Research

Netherlands Organisation for Health Research and Development

NIDDK

Boston University School of Medicine

Robert Dawson Evans Endowment

National Center on Minority Health and Health Disparities

Center for Inherited Disease Research

Center for Research on Genomics and Global Health

Center for Information Technology

Office of the Director of the NIH

Coriell Institute for Medical Research

Scottish Government Health and Social Care Directorates

Scottish Funding Council

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Centre National de Génotypage

NWO

International Development Research Center

World Health Organization

Overseas Development Administration

European Union

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Brazilian National Research Council

Brazilian Ministry of Health

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Funding of Studies and Projects

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Ministry of Education, Culture and Science

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Genetic Laboratory of the Department of Internal Medicine, Erasmus MC

Netherlands Genomics Initiative

Netherlands Consortium for Healthy Aging

National Medical Research Council

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Hebrew University of Jerusalem

National Research Foundation

National Cancer Institute

Wake Forest University

Home Office

National Institute for Health Researc

Imperial College Healthcare NHS Trust

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National Health Service Multi-site Research Ethics Committee

MRC

UK Medical Bioinformatics Partnership Programme

Public Health England

NIHR Health Protection Research Unit in Health Impact of Environmental Hazards

NIHR

NIHR Barts Biomedical Research Centre

National Key Laboratory Fund

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Sciences and Technology

British Heart Foundation

Japan Science and Technology Agency

National Institute of Biomedical Innovation

National Center for Global Health and Medicine

German Research Center for Environmental Health

German Federal Ministry of Education and Research

State of Bavaria

Munich Center of Health Sciences

Caisse Nationale d’Assurance Maladie des Travailleurs Salariés

Eli Lilly and Company

Novartis Pharmaceuticals Corporation

Sanofi-Aventis France S.A.

INSERM

Association Diabète Risque Vasculaire

Fédération Française de Cardiologie

Association de Langue Française pour l’Etude du Diabète et des Maladies Métabolique

Office National Interprofessionnel des Vins

Société Francophone du Diabète

Ardix Medical

Bayer Diagnostics

Becton Dickinson

Cardionics, Inc.

Novo Nordisk

Laboratoires Pierre Fabre

Roche, Inc.

Topcon Corporation

National Basic Research Program

Programme of Introducing Talents of Discipline

National Natural Science Foundation of China

Program for the New Century Excellent Talents in University

Ministry of Education and Culture of Finland

Academy of Finland

City of Kuopio

Juho Vainio Foundation

Finnish Diabetes Association

Finnish Foundation for Cardiovascular Research

Kuopio University Hospital

Päivikki and Sakari Sohlberg Foundation

Social Insurance Institution of Finland

European Union H2020

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Nordic Information for Action eScience Center

European Institute for Innovation and Technology

European Regional Development Fund

Cancer Research UK

Ministry of Agriculture

Fisheries and Food

Commission of the European Communities

Swedish Research Council

Swedish Heart-Lung Foundation

European Research Council

Skåne Health Authority

NIHR Leicester Cardiovascular Biomedical Research Unit

National Institute of Nursing Research

Johns Hopkins Institute for Clinical and Translational Research

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Office of Dietary Supplements

Illumina, Inc.

Regione Friuli-Venezia Giulia

Italian Ministry of Health

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Province of Groningen

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Dutch Kidney Foundation

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ZonMw

Sixth Framework Program

AstraZeneca plc

Knut and Alice Wallenberg Foundation

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Foundation for Strategic Research

Stockholm County Council

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Swedish Research Council for Health, Working Life and Welfare

Swedish Heart and Lung Foundation

Cardiovascular Programme at Karolinska Institutet

Federal Ministry of Education and Research

Ministry of Cultural Affairs

Social Ministry of the Federal State of Mecklenburg-West Pomerania

Siemens Healthcare

Federal State of Mecklenburg-West Pomerania

GenomEUtwin

Swedish Foundation for Strategic Research

Heart and Lung Foundation

Kuopio, Tampere and Turku University Hospital Medical Funds

Paavo Nurmi Foundation

Finnish Cultural Foundation

Tampere Tuberculosis Foundation

Emil Aaltonen Foundation

Yrjö Jahnsson Foundation

Signe and Ane Gyllenberg Foundation

Diabetes Research Foundation of the Finnish Diabetes Association

Publisher

Oxford University Press (OUP)

Subject

Epidemiology

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