Practical genetic control strategies for industrial bioprocesses-Reference-Cited by-同舟云学术

Practical genetic control strategies for industrial bioprocesses

Published:2022-02-02 Issue:2 Volume:49 Page:
ISSN:1367-5435
Container-title:Journal of Industrial Microbiology and Biotechnology
language:en
Short-container-title:

Author:

Moore Jonathan C¹,Ramos Itzel²,Van Dien Stephen³^ORCID

Affiliation:

1. No current affiliation, Encinitas, CA 92024, USA

2. BP Biosciences Center, San Diego, CA 92121, USA

3. Persephone Biosciences, San Diego, CA 92121, USA

Abstract

Abstract Optimization of metabolism to maximize production of bio-based chemicals must consistently balance cellular resources for biocatalyst growth and desired compound synthesis. This mini-review discusses synthetic biology strategies for dynamically controlling expression of genes to enable dual-phase fermentations in which growth and production are separated into dedicated phases. Emphasis is placed on practical examples which can be reliably scaled to commercial production with the current state of technology. Recent case studies are presented, and recommendations are provided for environmental signals and genetic control circuits.

Publisher

Oxford University Press (OUP)

Subject

Applied Microbiology and Biotechnology,Biotechnology,Bioengineering

Link

https://academic.oup.com/jimb/advance-article-pdf/doi/10.1093/jimb/kuab088/42682311/kuab088.pdf

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