Hypopigmented white patches in a newborn

Abstract

A newborn developed multiple hyperkeratotic erythematous papules, some with central erosions, mainly located on her scalp and trunk. Histopathology revealed a dense infiltrate of monotonous mononuclearcells with pale pink cytoplasm and reniform nuclei, positive for CD1a, S100 protein, and langerin. A diagnosis of congenital self-healing Langerhans cell histiocytosis was made. Extracutaneous involvement was excluded and the patient is stable at 3 months follow-up. Congenital Self-Healing Langerhans cell histiocytosis (CSHLCH) is a rare variant of LCH. Long term follow up is recommended, as relapse of cutaneous manifestations or subsequent visceral involvement have been described, especially in the first year of life.