Affiliation:
1. Department of Dermatology, Yonsei University Wonju College of Medicine , Wonju, Republic of Korea
Abstract
Abstract
Background
Various comorbid diseases have been reported in patients with lichen planopilaris (LPP); however, data regarding the risks of incident diseases and mortality are lacking.
Objectives
To investigate the risks of incident diseases and mortality associated with LPP.
Methods
This was a retrospective nationwide population-based study, using data from the National Health Insurance Service Database of Korea from 2002 to 2019. Patients aged ≥ 18 years with three or more documented medical visits for LPP were included. The adjusted hazard ratios (aHRs) for incident disease outcomes and mortality were compared with 1 : 20 age-, sex-, insurance type- and income-level-matched controls.
Results
In total, 2026 patients with LPP and 40 520 controls were analysed. The risks of incident systemic lupus erythematosus [aHR 1.91, 95% confidence interval (CI) 1.21–3.03], psoriasis (aHR 3.42, 95% CI 2.83–4.14), rheumatoid arthritis (aHR 1.39, 95% CI 1.19–1.63), lichen planus (aHR, 10.07, 95% CI 7.17–14.15), atopic dermatitis (aHR 2.15, 95% CI 1.90–2.44), allergic rhinitis (aHR 1.29, 95% CI 1.13–1.49), thyroid diseases (hyperthyroidism: aHR 1.42, 95% CI 1.14–1.77, hypothyroidism aHR 1.19 95% CI 1.01–1.41, and thyroiditis: aHR, 1.35, 95% CI 1.08–1.69), nonmelanoma skin cancer (aHR 2.33, 95% CI 1.00–5.44) and vitamin D deficiency (aHR 1.23, 95% CI 1.03–1.47) were higher in patients with LPP. Patients with LPP had a higher mortality rate than controls (aHR 1.30, 95% CI 1.04–1.61), although the risk was not significant after adjusting for comorbidities (aHR 1.08, 95% CI 0.87–1.34).
Conclusions
Patients with LPP had a higher risk of various diseases following LPP diagnosis. Close follow-up is needed to optimize comprehensive patient care.
Funder
National Research Foundation
Korean government
Publisher
Oxford University Press (OUP)
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献