A Novel Antigen, Otubain Cysteine Peptidase of Leishmania donovani, for the Serodiagnosis of Visceral Leishmaniasis and for Monitoring Treatment Response-Reference-Cited by-同舟云学术

A Novel Antigen, Otubain Cysteine Peptidase of Leishmania donovani, for the Serodiagnosis of Visceral Leishmaniasis and for Monitoring Treatment Response

Published:2021-05-14 Issue:7 Volume:73 Page:1281-1283
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Kamran Mohd¹,Ejazi Sarfaraz Ahmad¹,Choudhury Somsubhra Thakur¹,Bhattacharyya Anirban¹,Tanishka Km¹,Pandey Krishna²,Das Vidya Nand Ravi²,Das Pradeep²,da Silva Fernando Oliveira³,Costa Dorcas Lamounier³,Costa Carlos Henrique Nery³,Rahaman Mehebubar⁴,Goswami Rama Prosad⁴,Ali Nahid¹

Affiliation:

1. Infectious Diseases and Immunology Division, Council of Scientific and Industrial Research–Indian Institute of Chemical Biology, Kolkata, India

2. Rajendra Memorial Research Institute of Medical Sciences, Patna, India

3. Universidade Federal do Piaui, Teresina, Brazil

4. Department of Tropical Medicine, School of Tropical Medicine, Kolkata, India

Abstract

Abstract Tests for visceral leishmaniasis (VL) are not uniformly effective for all endemic regions. In a serological assay, a novel antigen, otubain cysteine peptidase, compared with rK39, showed comparable sensitivity with Indian VL serum samples and prominently increased sensitivity with Brazilian samples, as well as improved monitoring of the treatment response.

Funder

A Global Network for Neglected Tropical Diseases

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab435/38895192/ciab435.pdf

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