Waning Vaccine Effectiveness Against Influenza-Associated Hospitalizations Among Adults, 2015–2016 to 2018–2019, United States Hospitalized Adult Influenza Vaccine Effectiveness Network

Author:

Ferdinands Jill M1,Gaglani Manjusha2,Martin Emily T3,Monto Arnold S3,Middleton Donald4,Silveira Fernanda4,Talbot H Keipp5,Zimmerman Richard4,Patel Manish1

Affiliation:

1. Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

2. Baylor Scott & White Health System, Temple, Texas, USA

3. University of Michigan School of Public Health, Ann Arbor, Michigan, USA

4. University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA

5. Vanderbilt University Medical Center, Nashville, Tennessee, USA

Abstract

Abstract We observed decreased effectiveness of influenza vaccine with increasing time since vaccination for prevention of influenza A(H3N2), influenza A(H1N1)pdm09, and influenza B/Yamagata–associated hospitalizations among adults. Maximum vaccine effectiveness (VE) was observed shortly after vaccination, followed by an absolute decline in VE of about 8%–9% per month postvaccination.

Funder

Centers for Disease Control and Prevention

National Institutes of Health

National Center for Advancing Translational Sciences

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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