Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Naive Nursing Home Residents-Reference-Cited by-同舟云学术

Reduced BNT162b2 Messenger RNA Vaccine Response in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)–Naive Nursing Home Residents

Published:2021-05-16 Issue:11 Volume:73 Page:2112-2115
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Canaday David H¹²,Carias Lenore¹,Oyebanji Oladayo A¹,Keresztesy Debbie¹,Wilk Dennis¹,Payne Michael¹,Aung Htin¹,St. Denis Kerri³,Lam Evan C³,Rowley Christopher F⁴,Berry Sarah D⁵,Cameron Cheryl M¹,Cameron Mark J¹,Wilson Brigid²,Balazs Alejandro B³,Gravenstein Stefan⁶⁷,King Christopher L¹⁸

Affiliation:

1. Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

2. Geriatric Research, Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA

3. Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA

4. Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA

5. Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts, USA

6. Division of Geriatrics and Palliative Medicine, Alpert Medical School of Brown University, Providence, Rhode Island, USA

7. Center on Innovation in Long-Term Services and Supports, Providence Veterans Affairs Medical Center, Providence, Rhode Island, USA

8. Division of Infectious Diseases, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA

Abstract

Abstract After BNT162b2 messenger RNA vaccination, antibody levels to spike, receptor-binding domain, and virus neutralization were examined in 149 nursing home residents and 110 healthcare worker controls. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–naive nursing home residents’ median post–second vaccine dose antibody neutralization titers are one-quarter that of SARS-CoV-2–naive healthcare workers.

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab447/38830418/ciab447.pdf

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3. Is the end of the long-term care crisis within sight? New COVID-19 cases and deaths in long-term care facilities are dropping;Chidambaram,2021