Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients-Reference-Cited by-同舟云学术

Circulating Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Published:2021-05-20 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Ogata Alana F¹²³,Cheng Chi-An¹²³,Desjardins Michaël³⁴⁵,Senussi Yasmeen¹,Sherman Amy C³⁴,Powell Megan⁴,Novack Lewis⁴,Von Salena⁴,Li Xiaofang⁶,Baden Lindsey R³⁴⁶,Walt David R¹²³

Affiliation:

1. Department of Pathology, Brigham and Women’s Hospital, Boston, Massachusetts, USA

2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, USA

3. Harvard Medical School, Boston, Massachusetts, USA

4. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA

5. Division of Infectious Diseases, Centre Hospitalier de l’Université de Montréal, Montreal, Quebec, Canada

6. Center for Clinical Investigation, Brigham and Women’s Hospital, Boston, Massachusetts, USA

Abstract

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins were measured in longitudinal plasma samples collected from 13 participants who received two doses of mRNA-1273 vaccine. Eleven of 13 participants showed detectable levels of SARS-CoV-2 protein as early as day 1 after first vaccine injection. Clearance of detectable SARS-CoV-2 protein correlated with production of immunoglobulin G (IgG) and immunoglobulin A (IgA).

Funder

Bill and Melinda Gates Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab465/39022805/ciab465.pdf

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