High False-Positive Rate of (1,3)-β-D-Glucan in Onco-Hematological Patients Receiving Immunoglobulins and Therapeutic Antibodies-Reference-Cited by-同舟云学术

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High False-Positive Rate of (1,3)-β-D-Glucan in Onco-Hematological Patients Receiving Immunoglobulins and Therapeutic Antibodies

Published:2022-01-06 Issue:2 Volume:75 Page:330-333
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Tschopp Jonathan¹,Brunel Anne Sophie¹,Spertini Olivier²,Croxatto Anthony³,Lamoth Frederic¹⁴,Bochud Pierre Yves¹

Affiliation:

1. Infectious Diseases Service, University Hospital and University of Lausanne , Lausanne , Switzerland

2. Hematology Service, University Hospital and University of Lausanne , Lausanne , Switzerland

3. ADMed Microbiologie , La Chaux-de-Fonds , Switzerland

4. Institute of Microbiology, University Hospital and University of Lausanne , Lausanne , Switzerland

Abstract

Abstract Immunoglobulins and/or therapeutic antibody preparations are associated with a high rate of false-positive (1,3)-β-D-glucan (BDG) tests in onco-hematological patients routinely screened for fungal infections. The benefit of BDG monitoring shall be balanced against the risk of false-positive tests leading to unnecessary investigations and costs in this population.

Funder

Swiss National Science Foundation

Leenaards Foundation

Santos-Suarez Foundation

Carigest

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab1028/42494456/ciab1028.pdf

Reference12 articles.

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4. Beta-D-glucan as a diagnostic adjunct for invasive fungal infections: validation, cutoff development, and performance in patients with acute myelogenous leukemia and myelodysplastic syndrome.;Odabasi;Clin Infect Dis,2004

5. Difficulties in using 1,3-{beta}-D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies—high frequency of false-positive results and their analysis.;Racil;J Med Microbiol,2010

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