Envisioning Future Urinary Tract Infection Diagnostics

Author:

Patel Robin12ORCID,Polage Christopher R3,Dien Bard Jennifer45,May Larissa6,Lee Francesca M7,Fabre Valeria8,Hayden Mary K9,Doernberg Sarah D B10,Haake David A11,Trautner Barbara W12,Grigoryan Larissa13,Tsalik Ephraim L14,Hanson Kimberly E15

Affiliation:

1. Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA

2. Division of Infectious Diseases, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA

3. Department of Pathology, Duke University Health System, Durham, North Carolina, USA

4. Department of Pathology and Laboratory Medicine, Children’s Hospital Los Angeles, Los Angeles, California, USA

5. Keck School of Medicine, University of Southern California, Los Angeles, California, USA

6. Department of Emergency Medicine, University of California-Davis Health, Sacramento, California, USA

7. Division of Infectious Diseases, Department of Pathology and Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA

8. Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

9. Division of Infectious Diseases, Division of Internal Medicine, Rush Medical College, Chicago, IL, USA

10. Division of Infectious Disease, Department of Medicine, University of California San Francisco, San Francisco, California, USA

11. Infectious Diseases Section, VA Greater Los Angeles Healthcare System, and the Division of Infectious Diseases, Department of Medicine, the David Geffen School of Medicine at UCLA, Los Angeles, California, USA

12. Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center and Department of Medicine, Baylor College of Medicine, Houston, Texas, USA

13. Center for Innovation in Quality Effectiveness and Safety, Michael E. DeBakay Veterans Affairs Medical Centetr; and and 15 Department of Family and Community Medicine, Baylor College of Medicine, Houston, Texas, USA

14. Duke University Center for Applied Genomics and Precision Medicine, Durham, NC, USA; Durham Veterans Affairs Health Care System, Durham, North Carolina, USA

15. Department of Internal Medicine and Department of Pathology, University of Utah, Salt Lake City, Utah, USA

Abstract

Abstract Urinary tract infections (UTIs) are among the most common bacterial infections in the United States and are a major driver of antibiotic use, both appropriate and inappropriate, across healthcare settings. Novel UTI diagnostics are a strategy that might enable better UTI treatment. Members of the Antibacterial Resistance Leadership Group Laboratory Center and the Infectious Diseases Society of America Diagnostics Committee convened to envision ideal future UTI diagnostics, with a view towards improving delivery of healthcare, patient outcomes and experiences, and antibiotic use, addressing which types of UTI diagnostics are needed and how companies might approach development of novel UTI diagnostics.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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