Comparative study of the PD-L1 status between surgically resected specimens and matched biopsies of NSCLC patients reveal major discordances: a potential issue for anti-PD-L1 therapeutic strategies

Author:

Ilie M.,Long-Mira E.,Bence C.,Butori C.,Lassalle S.,Bouhlel L.,Fazzalari L.,Zahaf K.,Lalvée S.,Washetine K.,Mouroux J.,Vénissac N.,Poudenx M.,Otto J.,Sabourin J.C.,Marquette C.H.,Hofman V.,Hofman P.

Funder

Fondation ARC pour la recherche sur le cancer

Boehringer-Ingelheim

France

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference22 articles.

1. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients;Herbst;Nature,2014

2. Immune checkpoint modulation for non-small cell lung cancer;Soria;Clin Cancer Res,2015

3. Refining the treatment of NSCLC according to histological and molecular subtypes;Thomas;Nat Rev Clin Oncol,2015

4. Clinical activity, safety and predictive biomarkers of the engineered antibody MPDL3280A (anti-PDL1) in non-small cell lung cancer (NSCLC): update from a phase Ia study;Horn;J Clin Oncol,2015

5. Efficacy, safety and predictive biomarker results from a randomized phase II study comparing atezolizumab vs docetaxel in 2L/3L NSCLC (POPLAR);Spira;J Clin Oncol,2015

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