Final report of the phase I/II clinical trial of the E75 (nelipepimut-S) vaccine with booster inoculations to prevent disease recurrence in high-risk breast cancer patients

Author:

Mittendorf E.A.,Clifton G.T.,Holmes J.P.,Schneble E.,van Echo D.,Ponniah S.,Peoples G.E.

Funder

United States Military Cancer Institute

Department of Surgery, Uniformed Services University of the Health Sciences

Clinical Breast Care Project

Department of Clinical Investigation, Walter Reed Army Medical Center

NIH

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference19 articles.

1. The E75 HER2/neu peptide vaccine;Mittendorf;Cancer Immunol Immunother,2008

2. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells;Brossart;Blood,2000

3. Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines;Disis;J Clin Oncol,2002

4. Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369–377, results in short-lived peptide-specific immunity;Knutson;Clin Cancer Res,2002

5. Immunization with a peptide epitope (p369–377) from HER-2/neu leads to peptide-specific cytotoxic T lymphocytes that fail to recognize HER-2/neu+ tumors;Zaks;Cancer Res,1998

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