Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues

Author:

Fumoleau P.,Coudert B.,Isambert N.,Ferrant E.

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference42 articles.

1. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol®);Kowalski;J Biol Chem,1997

2. Activity of epothilones;Kolman;Curr Opin Investig Drugs,2005

3. Suppression of microtubule dynamics by epothilone B is associated with mitotic arrest;Kamath;Cancer Res,2003

4. Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules;Hari;Mol Cancer Ther,2006

5. Epothilones A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (myxobacteria);Gerth;Production, physico-chemical and biological properties. J Antibiot (Tokyo),1996

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