Pharmacokinetic and safety study of subcutaneously administered weekly ING-1, a human engineered™ monoclonal antibody targeting human EpCAM, in patients with advanced solid tumors

Author:

Goel S.,Bauer R.J.,Desai K.,Bulgaru A.,Iqbal T.,Strachan B.-K.,Kim G.,Kaubisch A.,Vanhove G.F.,Goldberg G.,Mani S.

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference17 articles.

1. In vitro and in vivo pharmacology and pharmacokinetics of a human engineered™ monoclonal antibody to epithelial cell adhesion molecule;Ammons;Neoplasia,2003

2. New chimeric anti-pancarcinoma monoclonal antibody with superior cytotoxicity-mediating potency;Velders;Cancer Res,1994

3. Immunotherapy with low and high affinity monoclonal antibodies 17-1A and 323/A3 in a nude mouse xenograft carcinoma model;Velders;Cancer Res,1995

4. The role of monoclonal antibody affinity in tumor immunotherapy evaluated in in vivo models for minimal residual disease;Velders;J Immunother Emphasis Tumor Immunol,1996

5. Comparison of monoclonal antibodies 17-1A and 323/A3: the influence of the affinity on tumour uptake and efficacy of radioimmunotherapy in human ovarian cancer xenografts;Kievit;Br J Cancer,1996

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