Variations in genes regulating tumor-associated macrophages (TAMs) to predict outcomes of bevacizumab-based treatment in patients with metastatic colorectal cancer: results from TRIBE and FIRE3 trials

Author:

Sunakawa Y.,Stintzing S.,Cao S.,Heinemann V.,Cremolini C.,Falcone A.,Yang D.,Zhang W.,Ning Y.,Stremitzer S.,Matsusaka S.,Yamauchi S.,Parekh A.,Okazaki S.,Berger M.D.,Graver S.,Mendez A.,Scherer S.J.,Loupakis F.,Lenz H.-J.

Funder

National Institutes of Health

Dhont Family Foundation

San Pedro Peninsula Cancer Guild

Mildred-Scheel Foundation

Austrian Science Fund

Swiss Cancer League

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference22 articles.

1. Alternative activation of macrophages: mechanism and functions;Gordon;Immunity,2010

2. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes;Mantovani;Trends Immunol,2002

3. Inflammation meets cancer, with NF-kappaB as the matchmaker;Ben-Neriah;Nat Immunol,2011

4. Vascular endothelial growth factor secretion by tumor-infiltrating macrophages essentially supports tumor angiogenesis, and IgG immune complexes potentiate the process;Barbera-Guillem;Cancer Res,2002

5. High macrophage infiltration along the tumor front correlates with improved survival in colon cancer;Forssell;Clin Cancer Res,2007

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