Akt-induced endocrine therapy resistance is reversed by inhibition of mTOR signaling
Author:
Publisher
Elsevier BV
Subject
Oncology,Hematology
Link
http://academic.oup.com/annonc/article-pdf/18/8/1323/19446623/mdm170.pdf
Reference24 articles.
1. The protein kinase B/Akt signalling pathway in human malignancy;Nicholson;Cell Signal,2002
2. Increased constitutive activity of PKB/Akt in tamoxifen resistant breast cancer MCF-7 cells;Jordan;Breast Cancer Res Treat,2004
3. Inhibition of mTOR activity restores tamoxifen response in breast cancer cells with aberrant Akt activity;deGraffenried;Clin Cancer Res,2004
4. Reduced PTEN expression predicts relapse in patients with breast carcinoma treated by tamoxifen;Shoman;Mod Pathol,2004
5. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients;Perez-Tenorio;Br J Cancer,2002
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