Lack of correlation between immunohistochemical expression of E2F-1, thymidylate synthase expression and clinical response to5-fluorouracil in advanced colorectal cancer
Author:
Publisher
Elsevier BV
Subject
Oncology,Hematology
Link
http://academic.oup.com/annonc/article-pdf/15/1/55/332880/mdh018.pdf
Reference14 articles.
1. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors;Johnston;Cancer Res,1995
2. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin;Leichman;J Clin Oncol,1997
3. Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy;Aschele;J Clin Oncol,1999
4. Thymidylate synthase expression: an independent prognostic factor for local recurrence, distant metastasis, disease-free and overall survival in rectal cancer;Edler;Clin Cancer Res,2000
5. Cellular targets for activation by the E2F-1 transcription factor include DNA synthesis and G1/S regulatory genes;DeGregori;Mol Cell Biol,1995
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