Do Contemporary Randomized Controlled Trials Meet ESMO Thresholds for Meaningful Clinical Benefit?
Author:
Funder
Canada Research Chair in Population Cancer Care
Publisher
Elsevier BV
Subject
Oncology,Hematology
Link
http://academic.oup.com/annonc/article-pdf/28/1/157/10297012/mdw538.pdf
Reference15 articles.
1. Why do cancer drugs get such an easy ride?;Light;BMJ,2015
2. Evolution of the randomized controlled trial in oncology over three decades;Booth;J Clin Oncol,2008
3. Randomized controlled trials in the era of molecular oncology: methodology, biomarkers, and end points;Kay;Ann Oncol,2012
4. Bias in reporting of end points of efficacy and toxicity in randomized, clinical trials for women with breast cancer;Vera-Badillo;Ann Oncol,2013
5. A standardised, generic, validated approach to stratify the magnitude of clinical benefit that can be anticipated from anti-cancer therapies: the European Society for Medical Oncology Magnitude of Clinical Benefit Scale (ESMO-MCBS);Cherny;Ann Oncol,2015
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