The Macrophage ‘Do not eat me’ signal, CD47, is a clinically validated cancer immunotherapy target
Author:
Funder
Jens-Peter Volkmer
Forty Seven, Inc
Publisher
Elsevier BV
Subject
Oncology,Hematology
Link
http://academic.oup.com/annonc/article-pdf/30/3/486/28255120/mdz006.pdf
Reference22 articles.
1. Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding;Lindberg;J Cell Biol,1993
2. The CD47-SIRPalpha pathway in cancer immune evasion and potential therapeutic implications;Chao;Curr Opin Immunol,2012
3. Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47;Chao;Sci Transl Med,2010
4. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells;Majeti;Cell,2009
5. The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors;Willingham;Proc Natl Acad Sci USA,2012
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