Prevention of irinotecan plus5-fluorouracil/leucovorin-induced diarrhoea by oral administration of neomycin plus bacitracin in first-line treatment of advanced colorectal cancer

Author:

Alimonti A.,Satta F.,Pavese I.,Burattini E.,Zoffoli V.,Vecchione A.

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference5 articles.

1. Irinotecan (CPT-11) metabolism and disposition in cancer patients;Sparreboom;Clin Cancer Res,1998

2. Pharmacokinetic interrelationships of irinotecan (CPT-11) and its three major plasma metabolites in patients enrolled in phase I/II trials;Rivory;Clin Cancer Res,1997

3. Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea;Gupta;Cancer Res,1994

4. Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats;Takasuna;Cancer Chemother Pharmacol,1998

5. Modulation of irinotecan-induced diarrhea by cotreatment with neomycin in cancer patients;Kehrer;Clin Cancer Res,2001

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