Efficient targeted DNA methylation with chimeric dCas9–Dnmt3a–Dnmt3L methyltransferase

Author:

Stepper Peter1,Kungulovski Goran1,Jurkowska Renata Z.1,Chandra Tamir2,Krueger Felix3,Reinhardt Richard4,Reik Wolf2ORCID,Jeltsch Albert1,Jurkowski Tomasz P.1

Affiliation:

1. Institute of Biochemistry, Pfaffenwaldring 55, Faculty of Chemistry, University of Stuttgart, D-70569 Stuttgart, Germany

2. Epigenetics Programme, The Babraham Institute, Cambridge CB22 3AT, UK; The Welcome Trust Sanger Institute, Cambridge CB10 1SA, UK

3. The Babraham Institute, Cambridge CB22 3AT, UK

4. Max Planck Genome-Centre Cologne, Carl-von-Linné-Weg 10, D-50829 Cologne, Germany

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference41 articles.

1. Functions of DNA methylation: islands, start sites, gene bodies and beyond;Jones;Nat. Rev. Genet.,2012

2. DNA methylation dynamics in health and disease;Bergman;Nat. Struct. Mol. Biol.,2013

3. DNMT3A in haematological malignancies;Yang;Nat. Rev. Cancer,2015

4. The evolving epigenome;Weichenhan;Hum. Mol. Genet.,2013

5. The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a;Chedin;Proc. Natl. Acad. Sci. U.S.A.,2002

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