A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study-Reference-Cited by-同舟云学术

A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Published:2021-04-07 Issue:1 Volume:114 Page:338-347
ISSN:0002-9165
Container-title:The American Journal of Clinical Nutrition
language:en
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Author:

Clasen Joanna L¹^ORCID,Heath Alicia K¹^ORCID,Van Puyvelde Heleen²³,Huybrechts Inge²,Park Jin Young²,Ferrari Pietro²,Johansson Mattias²^ORCID,Scelo Ghislaine⁴,Ulvik Arve⁵,Midttun Øivind⁶,Ueland Per Magne⁵,Dahm Christina C⁷,Halkjær Jytte⁸,Olsen Anja⁸,Johnson Theron⁹^ORCID,Katzke Verena⁹^ORCID,Schulze Matthias B¹⁰¹¹,Masala Giovanna¹²^ORCID,Segrado Francesco¹³,de Magistris Maria Santucci¹⁴,Sacerdote Carlotta¹⁵^ORCID,Ocké Marga C¹⁶,Luján-Barroso Leila¹⁷¹⁸,Ching-López Ana¹⁹²⁰,Huerta José María²¹²²,Ardanaz Eva²²²³²⁴,Amiano Pilar²⁵,Ericson Ulrika²⁶^ORCID,Manjer Jonas²⁷,Gylling Björn²⁸,Johansson Ingegerd²⁹^ORCID,Schmidt Julie³⁰,Weiderpass Elisabete²,Riboli Elio¹^ORCID,Cross Amanda J¹,Muller David C¹³¹

Affiliation:

1. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

2. International Agency for Research on Cancer, Lyon, France

3. Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium

4. Cancer Epidemiology Unit, University of Turin, Turin, Italy

5. Department of Clinical Science, University of Bergen, Bergen, Hordaland, Norway

6. Bevital A/S, Bergen, Norway

7. Department of Public Health, Aarhus University, Aarhus, Denmark

8. Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark

9. German Cancer research Center (DKFZ), Heidelberg, Germany

10. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

11. Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany

12. Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy

13. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy

14. AOU Federico II, Naples, Italy

15. Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin Italy

16. National Institute for Public Health and the Environment, Bilthoven, The Netherlands

17. Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO), L'Hospitalet de Llobregat, Barcelona, Spain

18. Bellvitge Biomedical Research Institute — IDIBELL, L'Hospitalet de 18 Llobregat, Barcelona, Spain

19. Escuela Andaluza de Salud Pública (EASP), Granada, Spain

20. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

21. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain

22. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain

23. Navarra Public Health Institute, Pamplona, Spain

24. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain

25. Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian; CIBER Epidemiología y Salud Pública, Madrid, Spain

26. Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden

27. Dept of Surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden

28. Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden

29. Department of Odontology, Umeå University, Umeå, Sweden

30. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom

31. Department of Epidemiology and Biostatistics, School of Public Health, MRC-PHE Centre for Environment and Health, Imperial College London, London, United Kingdom

Abstract

ABSTRACT Background Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5′-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. Objectives We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3´-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. Medthods Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. Results In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50, 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84, 0.90]; Cysta:Cys 0.89 [95% CrI: 0.84, 0.94]; HKr 0.88 [95% CrI: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. Conclusions We found that 5 different markers, capturing different aspects of vitamin B6–related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.

Funder

NIHR

European Commission

Danish Cancer Society

Swedish Research Council Formas

EPIC

Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

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