Physical activity and fat-free mass during growth and in later life

Author:

Westerterp Klaas R1,Yamada Yosuke23,Sagayama Hiroyuki4,Ainslie Philip N5,Andersen Lene F6,Anderson Liam J57,Arab Lenore8,Baddou Issaad9,Bedu-Addo Kweku10,Blaak Ellen E11,Blanc Stephane1213,Bonomi Alberto G14,Bouten Carlijn V C15,Bovet Pascal16,Buchowski Maciej S17,Butte Nancy F18,Camps Stefan G J A11,Close Graeme L5,Cooper Jamie A12,Das Sai K19,Cooper Richard20,Dugas Lara R20,Ekelund Ulf21,Entringer Sonja2223,Forrester Terrence24,Fudge Barry W25,Goris Annelies H11,Gurven Michael26,Hambly Catherine27,El Hamdouchi Asmaa9,Hoos Marije B11,Hu Sumei28,Joonas Noorjehan29,Joosen Annemiek M11,Katzmarzyk Peter30,Kempen Kitty P11,Kimura Misaka2,Kraus William E31,Kushner Robert F32ORCID,Lambert Estelle V33,Leonard William R34,Lessan Nader35,Martin Corby K30,Medin Anine C636,Meijer Erwin P11,Morehen James C537,Morton James P5,Neuhouser Marian L38,Nicklas Theresa A18,Ojiambo Robert M3940,Pietiläinen Kirsi H41,Pitsiladis Yannis P42,Plange-Rhule Jacob10,Plasqui Guy43,Prentice Ross L38,Rabinovich Roberto A44,Racette Susan B45,Raichlen David A46,Ravussin Eric30ORCID,Reynolds Rebecca M47,Roberts Susan B19ORCID,Schuit Albertine J48,Sjödin Anders M49,Stice Eric50,Urlacher Samuel S51,Valenti Giulio11,Van Etten Ludo M11,Van Mil Edgar A52,Wells Jonathan C K53ORCID,Wilson George5,Wood Brian M5455,Yanovski Jack56,Yoshida Tsukasa4,Zhang Xueying2728,Murphy-Alford Alexia J57,Loechl Cornelia U57,Luke Amy H58,Pontzer Herman5960,Rood Jennifer30,Schoeller Dale A61,Wong William W18,Speakman John R27286263,Branth Stefan64,Colbert Lisa H65,De Bruin Niels C66,Dutman Alice E67,Elmståhl Sölve68,Fogelholm Mikael69,Harris Tamara70,Heijligenberg Rik71,Jorgensen Hans U72,Larsson Christel L,Rothenberg Elisabet M73,McCloskey Margaret74,Meijer Gerwin A,Pannemans Daphne L,Schulz Sabine,Van den Berg-Emons Rita,Van Gemert Wim G,Wilhelmine W,Verboeket-van de Venne,Verbunt Jeanine A75,Philippaerts Renaat M76,Subar Amy77,Tanskanen Minna78,Uauy Ricardo79,Velthuis-te Wierik Erica J80,

Affiliation:

1. School of Nutrition and Translational Research in Metabolism, University of Maastricht, Maastricht, The Netherlands

2. National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan

3. Institute for Active Health, Kyoto University of Advanced Science, Kyoto, Japan

4. Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan

5. Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom

6. Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway

7. Crewe Alexandra Football Club, Crewe, United Kingdom

8. David Geffen School of Medicine, University of California, Los Angeles, CA, USA

9. Unité Mixte de Recherche en Nutrition et Alimentation, CNESTEN–Université Ibn Tofail URAC39, Regional Designated Center of Nutrition Associated with African Regional Agreement for Research/International Atomic Energy Agency, Rabat, Morocco

10. Department of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

11. Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands

12. Nutritional Sciences, University of Wisconsin, Madison, WI, USA

13. Institut Pluridisciplinaire Hubert Curien. CNRS Université de Strasbourg, UMR7178, Strasbourg, France

14. Phillips Research, Eindhoven, The Netherlands

15. Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands

16. University Center for Primary Care and Public Health (Unisanté), Lausanne, Switzerland

17. Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University, Nashville, TN, USA

18. Department of Pediatrics, Baylor College of Medicine, USDA/Agricultural Research Service Children's Nutrition Research Center, Houston, TX, USA

19. Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA

20. Department of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA

21. Department of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway

22. Institute of Medical Psychology, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany

23. Department of Pediatrics, University of California Irvine, Irvine, CA, USA

24. Solutions for Developing Countries, University of the West Indies, Mona, Kingston, Jamaica

25. Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom

26. Department of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA

27. Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, United Kingdom

28. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China

29. Central Health Laboratory, Ministry of Health and Wellness, Port Louis, Mauritius

30. Pennington Biomedical Research Center, Baton Rouge, LA, USA

31. Department of Medicine, Duke University, Durham, NC, USA

32. Department of Medicine, Northwestern University, Chicago, IL, USA

33. Research Unit for Exercise Science and Sports Medicine, University of Cape Town, Cape Town, South Africa

34. Department of Anthropology, Northwestern University, Evanston, IL, USA

35. Imperial College London Diabetes Centre, Imperial College London, London, United Kingdom

36. Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Kristiansand, Norway

37. The FA Group, Burton-Upon-Trent, United Kingdom

38. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center and School of Public Health, University of Washington, Seattle, WA, USA

39. Department of Medical Physiology, Moi University, Eldoret, Kenya

40. Department of Biomedical Sciences, University of Global Health Equity, Butaro, Rwanda

41. Helsinki University Central Hospital, Helsinki, Finland

42. Collaborating Centre of Sports Medicine, University of Brighton, Eastbourne, United Kingdom

43. Department of Nutrition and Movement Sciences, Maastricht University, Maastricht, The Netherlands

44. Department of Respiratory Medicine, University of Edinburgh, Edinburgh, United Kingdom

45. Program in Physical Therapy and Department of Medicine, Washington University School of Medicine, St Louis, MO, USA

46. Biological Sciences and Anthropology, University of Southern California, Los Angeles, CA, USA

47. Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom

48. School of Social and Behavioural Sciences, University of Tilburg, Tilburg, The Netherlands

49. Department of Nutrition, Exercise and Sports, Copenhagen University, Copenhagen, Denmark

50. Department of Psychiatry, Stanford University, Stanford, CA, USA

51. Department of Anthropology, Baylor University, Waco, TX, USA

52. Faculty of Health, Medicine and Life Sciences, and Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands

53. Population, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, United Kingdom

54. Department of Antropology, University of California Los Angeles, Los Angeles, CA, USA

55. Department of Human Behavior, Ecology, and Culture, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany

56. Section on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA

57. Nutritional and Health-Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria

58. Division of Epidemiology, Department of Public Health Sciences, Loyola University School of Medicine, Maywood, IL, USA

59. Evolutionary Anthropology, Duke University, Durham, NC, USA

60. Duke Global Health Institute, Duke University, Durham, NC, USA

61. Biotech Center and Nutritional Sciences, University of Wisconsin, Madison, WI, USA

62. Center for Energy Metabolism and Reproduction, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China

63. CAS Center of Excellence in Animal Evolution and Genetics, Kunming, China

64. University of Uppsala, Uppsala, Sweden

65. Kinesiology, University of Wisconsin, Madison, WI, USA

66. Erasmus University, Rotterdam, Netherlands

67. TNO Quality of Life, Zeist, Netherlands

68. Lund University, Lund, Sweden

69. Department of Food and Nutrition, Helsinki, Finland

70. NIH, Bethesda, MD, USA

71. Academic Medical Center of Amsterdam University, Amsterdam, Netherlands

72. Bispebjerg Hospital, Copenhagen, Denmark

73. University of Gothenburg, Gothenburg, Sweden

74. Royal Belfast Hospital for Sick Children, Belfast, United Kingdom

75. Maastricht University, Maastricht, Netherlands

76. Katholieke University Leuven, Leuven, Belgium

77. Epidemiology and Genomics, Division of Cancer Control, NIH, Bethesda, MD, USA

78. University of Jyväskilä, Jyväskilä, Finland

79. Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile

80. TNO Nutrition and Food Research Institute, Zeist, Netherlands

Abstract

ABSTRACT Background Physical activity may be a way to increase and maintain fat-free mass (FFM) in later life, similar to the prevention of fractures by increasing peak bone mass. Objectives A study is presented of the association between FFM and physical activity in relation to age. Methods In a cross-sectional study, FFM was analyzed in relation to physical activity in a large participant group as compiled in the International Atomic Energy Agency Doubly Labeled Water database. The database included 2000 participants, age 3–96 y, with measurements of total energy expenditure (TEE) and resting energy expenditure (REE) to allow calculation of physical activity level (PAL = TEE/REE), and calculation of FFM from isotope dilution. Results PAL was a main determinant of body composition at all ages. Models with age, fat mass (FM), and PAL explained 76% and 85% of the variation in FFM in females and males < 18 y old, and 32% and 47% of the variation in FFM in females and males ≥ 18 y old, respectively. In participants < 18 y old, mean FM-adjusted FFM was 1.7 kg (95% CI: 0.1, 3.2 kg) and 3.4 kg (95% CI: 1.0, 5.6 kg) higher in a very active participant with PAL = 2.0 than in a sedentary participant with PAL = 1.5, for females and males, respectively. At age 18 y, height and FM–adjusted FFM was 3.6 kg (95% CI: 2.8, 4.4 kg) and 4.4 kg (95% CI: 3.2, 5.7 kg) higher, and at age 80 y 0.7 kg (95% CI: −0.2, 1.7 kg) and 1.0 kg (95% CI: −0.1, 2.1 kg) higher, in a participant with PAL = 2.0 than in a participant with PAL = 1.5, for females and males, respectively. Conclusions If these associations are causal, they suggest physical activity is a major determinant of body composition as reflected in peak FFM, and that a physically active lifestyle can only partly protect against loss of FFM in aging adults.

Funder

National Science Foundation

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3