Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect-Reference-Cited by-同舟云学术

Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect

Published:2016-10-13 Issue: Volume: Page:ddw343
ISSN:0964-6906
Container-title:Human Molecular Genetics
language:en
Short-container-title:Hum. Mol. Genet.

Author:

Vaclová Tereza,Woods Nicholas T.,Megías Diego,Gomez-Lopez Sergio,Setién Fernando,García Bueno José María,Macías José Antonio,Barroso Alicia,Urioste Miguel,Esteller Manel,Monteiro Alvaro N.A.,Benítez Javier,Osorio Ana

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Link

http://academic.oup.com/hmg/article-pdf/25/24/5287/10408539/ddw343.pdf

Reference48 articles.

1. A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

2. The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

3. Opportunities and hurdles in the treatment of BRCA1-related breast cancer;Drost;Oncogene,2014

4. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

5. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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