RNA N6-methyladenosine modification in arthritis: New insights into pathogenesis

Author:

Chen Haowei1ORCID,Xuan Anran1,Shi Xiaorui1,Fan Tianxiang12,Xue Song13,Ruan Jianzhao1,Wang Xiaoshuai1,Tang Su’an1,Qi Weizhong1,Sun Haitao4,Liu Canzhao5,He Shuai6,Ding Changhai178ORCID,Zhu Zhaohua19ORCID

Affiliation:

1. Clinical Research Centre, Zhujiang Hospital, Southern Medical University , Guangzhou, China

2. Department of Rehabilitation Sciences, The Hong Kong Polytechnic University , Hong Kong SAR, China

3. Department of Rheumatology, The First Affiliated Hospital of Anhui Medical University , Hefei, China

4. Department of Neurosurgery, Zhujiang Hospital, Southern Medical University , Guangzhou, China

5. Department of Cardiovascular Medicine, Translational Medicine Research Center, Zhujiang Hospital, Southern Medical University , Guangzhou, China

6. Department of Pharmacy, Zhujiang Hospital, Southern Medical University , Guangzhou, China

7. Department of Rheumatology, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology , Guangzhou, China

8. Menzies Institute for Medical Research, University of Tasmania , Hobart, Tasmania, Australia

9. Department of Rheumatology, Royal North Shore Hospital and Sydney Musculoskeletal Health , Kolling Institute, University of Sydney, Sydney, Australia

Abstract

ABSTRACT The commonest type of eukaryotic RNA modification, N6-methyladenosine (m6A), has drawn increased scrutiny in the context of pathological functioning as well as relevance in determination of RNA stability, splicing, transportation, localization, and translation efficiency. The m6A modification plays an important role in several types of arthritis, especially osteoarthritis and rheumatoid arthritis. Recent studies have reported that m6A modification regulates arthritis pathology in cells, such as chondrocytes and synoviocytes via immune responses and inflammatory responses through functional proteins classified as writers, erasers, and readers. The aim of this review was to highlight recent advances relevant to m6A modification in the context of arthritis pathogenesis and detail underlying molecular mechanisms, regulatory functions, clinical applications, and future perspectives of m6A in arthritis with the aim of providing a foundation for future research directions.

Publisher

Oxford University Press (OUP)

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