Factors associated with discrepancies in disease activity as assessed by SDAI and RAPID3 in patients with rheumatoid arthritis: Data from a multicentre observational study (T-FLAG)

Author:

Suzuki Mochihito12ORCID,Asai Shuji1ORCID,Ohashi Yoshifumi134,Sobue Yasumori5,Ishikawa Hisato5,Takahashi Nobunori4,Terabe Kenya1ORCID,Sato Ryo1,Kosugiyama Hironobu1,Hasegawa Junya1,Ohno Yusuke1,Sugiura Takaya1,Imagama Shiro1ORCID

Affiliation:

1. Department of Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Aichi, Japan

2. Department of Orthopedic Surgery, Japan Community Health care Organization Kani Tono Hospital , Gifu, Japan

3. Department of Orthopedic Surgery, Yokkaichi Municipal Hospital , Mie, Japan

4. Department of Orthopedic Surgery, Aichi Medical University , Aichi, Japan

5. Department of Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital , Aichi, Japan

Abstract

ABSTRACT Objectives The present study aimed to examine discrepancies between assessments based on Routine Assessment of Patient Index Data 3 (RAPID3) and Simple Disease Activity Index (SDAI) in rheumatoid arthritis (RA) patients with controlled disease activity. Methods Data from 464 RA patients in SDAI remission or low disease activity (REM/LDA) were analysed. Patient-reported outcome (PRO) measures, including Health Assessment Questionnaire Disability Index (HAQ-DI), 25-question Geriatric Locomotive Function Scale (GLFS-25), and Kihon checklist (KCL), were assessed. Logistic regression models were used to identify factors associated with RAPID3 moderate or high disease activity (MDA/HDA). Cutoff values of RAPID3 MDA/HDA for each PRO evaluation item were determined using receiver operating characteristic curve analysis. Results Among RA patients in SDAI REM/LDA, 84.9% were in RAPID3 REM/LDA. Multivariable analysis revealed that HAQ-DI, GLFS-25, and KCL were independently associated with RAPID3 MDA/HDA. Subdomain analysis of KCL revealed that activities of daily living, physical function, cognitive function, and depressive mood were significantly associated with RAPID3 MDA/HDA. Cutoff values for HAQ-DI and KCL were 0.38 and 8, respectively. Conclusions In RA patients with controlled disease activity, discrepancies between RAPID3 and SDAI assessments were observed, with factors such as HAQ-DI, GLFS-25, and KCL being independently associated with RAPID3 MDA/HDA.

Publisher

Oxford University Press (OUP)

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