Response Inhibition in Adolescents is Moderated by Brain Connectivity and Social Network Structure

Abstract

Abstract The social environment an individual is embedded in influences their ability and motivation to engage self-control processes, but little is known about the neural mechanisms underlying this effect. Many individuals successfully regulate their behavior even when they do not show strong activation in canonical self-control brain regions. Thus, individuals may rely on other resources to compensate, including daily experiences navigating and managing complex social relationships that likely bolster self-control processes. Here, we employed a network neuroscience approach to investigate the role of social context and social brain systems in facilitating self-control in adolescents. We measured brain activation using fMRI as 62 adolescents completed a Go/No-Go response inhibition task. We found that self-referential brain systems compensate for weaker activation in executive function brain systems, especially for adolescents with more friends and more communities in their social networks. Collectively, our results indicate a critical role for self-referential brain systems during the developmental trajectory of self-control throughout adolescence.