Improving biobehavioral health in younger breast cancer survivors: Pathways to Wellness trial secondary outcomes

Author:

Bower Julienne E1234ORCID,Partridge Ann H56,Wolff Antonio C7,Cole Steve W2348,Irwin Michael R1234,Thorner Elissa D7,Joffe Hadine91011ORCID,Petersen Laura4ORCID,Crespi Catherine M412,Ganz Patricia A4813

Affiliation:

1. Department of Psychology, University of California, Los Angeles , Los Angeles, CA, USA

2. Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA, USA

3. Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles , Los Angeles, CA, USA

4. Jonsson Comprehensive Cancer Center, University of California, Los Angeles , Los Angeles, CA, USA

5. Department of Medical Oncology, Dana Farber Cancer Institute , Boston, MA, USA

6. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA, USA

7. The Johns Hopkins University School of Medicine and Sidney Kimmel Comprehensive Cancer Center , Baltimore, MD, USA

8. Department of Medicine (Hematology-Oncology), David Geffen School of Medicine, University of California, Los Angeles , Los Angeles, CA, USA

9. Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital, Harvard Medical School , Boston, MA, USA

10. Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School , Boston, MA, USA

11. Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute , Boston, MA, USA

12. Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles , Los Angeles, CA, USA

13. Department of Health Policy and Management, Fielding School of Public Health, University of California, Los Angeles , Los Angeles, CA, USA

Abstract

Abstract Background The Pathways to Wellness trial tested the efficacy of 2 interventions for younger breast cancer survivors: mindful awareness practices (MAPs) and survivorship education (SE). This planned secondary analysis examines intervention effects on stress, positive psychological outcomes, and inflammation (Clincaltrials.gov NCT03025139). Methods Women diagnosed with breast cancer at or before age 50 years who had completed treatment and had elevated depressive symptoms were randomly assigned to 6 weeks of MAPs, SE, or wait-list control (WLC). Assessments conducted at pre- and postintervention and at 3- and 6-month follow-up measured general stress perceptions, cancer-related intrusive thoughts and worry, positive affect, meaning and peace in life, altruism and empathy, and markers of inflammation. Analyses compared change in outcomes over time in each intervention group relative to WLC using linear mixed models. Results A total 247 women were randomly assigned to MAPs (n = 85), SE (n = 81), or WLC (n = 81). MAPs statistically significantly decreased intrusive thoughts and worry at postintervention and 3-month follow-up relative to WLC (P < .027) and statistically significantly increased positive affect and meaning and peace at postintervention, with positive affect persisting at 3-month follow-up (P < .027). SE statistically significantly decreased intrusive thoughts at 3-month follow-up and statistically significantly increased positive affect at 6-month follow-up relative to WLC (P < .01). Proinflammatory gene expression increased in WLC relative to MAPs (P = .016) but did not differ from SE. There were no intervention effects on other outcomes. Conclusion MAPs had beneficial effects on psychological and immune outcomes in younger breast cancer survivors and is a promising approach for enhancing biobehavioral health.

Funder

National Cancer Institute

National Institutes of Health

National Center for Advancing Translational Science

Breast Cancer Research Foundation

BCRF Scientific Advisory Board

Komen Foundation

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3