Targeting fusion oncoproteins in childhood cancers: challenges and future opportunities for developing therapeutics

Author:

Verma Sharad K1ORCID,Witkin Keren L2,Sharman Anu2,Smith Malcolm A1

Affiliation:

1. Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA

2. Division of Cancer Biology, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA

Abstract

Abstract Fusion oncoproteins are associated with childhood cancers and have proven challenging to target, aside from those that include kinases. As part of its efforts for targeting childhood cancers, the National Cancer Institute recently conducted a series on Novel Chemical Approaches for Targeting Fusion Oncoproteins. Key learnings on leading platforms and technologies that can be used to advance the development of molecular therapeutics that target fusion oncoproteins in childhood cancers are described. Recent breakthroughs in medicinal chemistry and chemical biology provide new ground and creative strategies to exploit for the development of targeted agents for improving outcomes against these recalcitrant cancers.

Funder

National Cancer Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

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