Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions

Author:

Lam W K Jacky12345ORCID,King Ann D6ORCID,Miller Jacob A7ORCID,Liu Zhiwei8ORCID,Yu Kelly J8,Chua Melvin L K91011,Ma Brigette B Y412,Chen Ming Yuan1314,Pinsky Benjamin A15ORCID,Lou Pei-Jen16,Woo John K S5,Hsu Wan-Lun1718,Simon Julia19,Doolan Denise L20,Waterboer Tim19,Hui Edwin P412,Li Hui21,Tsang Raymond K22,Wong Kenneth C W412,Goh Julian P23,Vlantis Alexander C5,Ai Qi Yong624,Wong Lun M6,Abdullah Victor2526,Lin Jin Ching27,Chen Chien-Jen28,Pfeiffer Ruth M8,Le Quynh-Thu7ORCID,Lee Anne W M2930,Ji Mingfang31ORCID,Cao Sumei1432,Ma Jun1433ORCID,Chan Anthony T C412,Chan K C Allen1234ORCID,Hildesheim Allan34

Affiliation:

1. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong , Hong Kong SAR, China

2. Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong SAR, China

3. Centre for Novostics, Hong Kong Science Park , Hong Kong SAR, China

4. State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong SAR, China

5. Department of Otorhinolaryngology, Head and Neck Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong SAR, China

6. Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong SAR, China

7. Department of Radiation Oncology, Stanford University , Stanford, CA, USA

8. Division of Cancer Epidemiology and Genetics, National Cancer Institute , Rockville, MD, USA

9. Department of Head and Neck and Thoracic Cancers, Division of Radiation Oncology, National Cancer Centre Singapore , Singapore, Singapore

10. Division of Medical Sciences, National Cancer Centre Singapore , Singapore, Singapore

11. Oncology Academic Programme, Duke-NUS Medical School , Singapore, Singapore

12. Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Sir YK Pao Centre for Cancer, Hong Kong Cancer Institute, The Chinese University of Hong Kong, Prince of Wales Hospital , Hong Kong SAR, China

13. Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong, China

14. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Center for Precision Medicine of Sun Yat-sen University, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong, China

15. Department of Pathology, Stanford University , Stanford, CA, USA

16. Department of Otolaryngology, National Taiwan University Hospital and College of Medicine , Taipei, Taiwan

17. Master Program of Big Data in Biomedicine, College of Medicine, Fu Jen Catholic University , New Taipei City, Taiwan

18. Data Science Center, College of Medicine, Fu Jen Catholic University , New Taipei City, Taiwan

19. Infections and Cancer Epidemiology, Infection, Inflammation and Cancer Program, German Cancer Research Center (DKFZ) , Heidelberg, Germany

20. Australian Institute of Tropical Health and Medicine, James Cook University , Cairns, Australia

21. Department of Radiology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China , Guangzhou, China

22. Department of Otolaryngology—Head and Neck Surgery, Yong Loo Lin School of Medicine, National University of Singapore , Singapore

23. Department of Diagnostic Radiology, Tan Tock Seng Hospital , Singapore, Singapore

24. Department of Health Technology and Informatics, The Hong Kong Polytechnic University , Hong Kong SAR, China

25. Department of Otorhinolaryngology, Hong Kong Children’s Hospital , Hong Kong SAR, China

26. The Hong Kong College of Otorhinolaryngologists , Hong Kong SAR, China

27. Department of Radiation Oncology, Changhua Christian Hospital , Changhua, Taiwan

28. Genomics Research Center, Academia Sinica , Taipei, Taiwan

29. Clinical Oncology Center, Shenzhen Key Laboratory for Cancer Metastasis and Personalized Therapy, The University of Hong Kong-Shenzhen Hospital , Guangdong, China

30. Department of Clinical Oncology, The University of Hong Kong , Hong Kong SAR, China

31. Cancer Research Institute of Zhongshan City, Zhongshan City People’s Hospital , Zhongshan, China

32. Department of Cancer Prevention, Sun Yat-sen University Cancer Center , Guangzhou, China

33. Department of Radiation Oncology, Sun Yat-sen University Cancer Center , Guangzhou, Guangdong, China

34. Agencia Costarricense de Investigaciones Biológicas (ACIB) - Fundacion del Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud (INCIENSA) , San José, Costa Rica

Abstract

AbstractA meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.

Funder

Innovation and Technology Commission of the Hong Kong SAR Government

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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