Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer-Reference-Cited by-同舟云学术

Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer

Published:2021-04-01 Issue: Volume: Page:
ISSN:0027-8874
Container-title:JNCI: Journal of the National Cancer Institute
language:en
Short-container-title:

Author:

Plym Anna¹²³^ORCID,Penney Kathryn L²⁴^ORCID,Kalia Sarah²,Kraft Peter²⁵⁶^ORCID,Conti David V⁷,Haiman Christopher⁷,Mucci Lorelei A²^ORCID,Kibel Adam S¹

Affiliation:

1. Urology Division, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

2. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

3. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden

4. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA

5. Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

6. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA

7. Department of Preventive Medicine, Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA

Abstract

Abstract Polygenic risk scores (PRSs) of common genetic variants have shown promise in prostate cancer risk stratification, but their validity across populations has yet to be confirmed. We evaluated a multiethnic PRS model based on 269 germline genetic risk variants (261 were available for analysis) using an independent population of 13 628 US men. The PRS was strongly associated with prostate cancer but not with any other disease. Comparing men in the top PRS decile with those at average risk (40%-60%), the odds ratio of prostate cancer was 3.89 (95% confidence interval = 3.24 to 4.68) for men of European ancestry and 3.81 (95% confidence interval = 1.48 to 10.19) for men of African ancestry. By age 85 years, the cumulative incidence of prostate cancer for European American men was 7.1% in the bottom decile and 54.1% in the top decile. This suggests that the PRS can be used to identify a substantial proportion of men at high risk for prostate cancer.

Funder

DiNovi Family Foundation, the National Cancer Institute at the National Institutes of Health

William Casey, the Swedish Society for Medical Research

Prostate Cancer Foundation

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

Link

http://academic.oup.com/jnci/advance-article-pdf/doi/10.1093/jnci/djab058/38130338/djab058.pdf

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