Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer-Reference-Cited by-同舟云学术

Geriatric assessment and quality of life for 2 years in older patients with head and neck cancer

Published:2024-02-09 Issue:5 Volume:116 Page:758-763
ISSN:0027-8874
Container-title:JNCI: Journal of the National Cancer Institute
language:en
Short-container-title:

Author:

Lafont Charlotte¹²³^ORCID,Paillaud Elena¹²⁴^ORCID,Bertolus Chloe⁵^ORCID,Baron Melany⁶,Caillet Philippe¹²⁴^ORCID,Bouvard Eric⁷,Laurent Marie¹²⁸,Salvan Didier⁹,Chaumette Laurence¹⁰,de Decker Laure¹¹^ORCID,Piot Benoit¹²,Barry Beatrix¹³^ORCID,Raynaud-Simon Agathe¹⁴^ORCID,Sauvaget Elisabeth¹⁵,Minard Aurélien¹⁶,Anota Amélie¹⁷¹⁸,Panjo Henri¹⁹^ORCID,Brugel Lydia²⁰,Canouï-Poitrine Florence¹²³^ORCID

Affiliation:

1. Univ Paris Est Creteil , , Creteil, France

2. INSERM, IMRB , , Creteil, France

3. Service de Santé Publique, AP-HP, Hôpital Henri-Mondor , Creteil, France

4. Département de Gériatrie, AP-HP, Paris Cancer Institute CARPEM, Hôpital Européen Georges Pompidou , Paris, France

5. Service de Chirurgie Maxillo-Faciale, AP-HP, Sorbonne Université, Hôpital Pitié Salpêtrière , Paris, France

6. Service de Soins de Suites et de Réadaptation Gériatrique, AP-HP, Sorbonne Université, Hôpitaux Universitaires Pitié Salpêtrière—Charles Foix , Ivry sur Seine, France

7. Service de Gériatrie, AP-HP, Hôpital Tenon , Paris, France

8. Département de Gériatrie, AP-HP, Hôpital Henri-Mondor , Créteil, France

9. Service ORL et Cervico-Facial, Centre Hospitalier Sud Francilien , Corbeil-Essonnes, France

10. Service de Court Sejour Gériatrique, Centre Hospitalier Sud Francilien , Corbeil-Essonnes, France

11. Service de Gériatrie, Centre Hospitalier Universitaire de Nantes , Nantes, France

12. Service de Chirurgie Maxillo-Faciale et Stomatologie, Centre Hospitalier Universitaire de Nantes , Nantes, France

13. Service ORL et Chirurgie Cervico-Faciale, AP-HP, Université de Paris, Hôpital Bichat , Paris, France

14. Service de Gériatrie, AP-HP, Université de Paris, Hôpital Bichat , Paris, France

15. Service ORL et Chirurgie Cervico-Faciale, Groupe Hospitalier Paris-Saint Joseph , Paris, France

16. Service de Gériatrie, Hôpital Léopold Bellan , Paris, France

17. Clinical Research and Innovation Department and Department of Human and Social Sciences, Centre Léon Bérard , Lyon, France

18. French National Platform Quality of Life and Cancer , Lyon, France

19. Université Paris-Saclay, UVSQ, Inserm, CESP , Villejuif, France

20. Service d’ORL et Chirurgie Cervico-Faciale, Centre Hospitalier Intercommunal de Créteil , Créteil, France

Abstract

Abstract Due to the location and toxicity of treatments, head and neck cancer (HNC) has a major impact on quality of life (QoL). Objective: to assess the effects of geriatric-assessment (GA)-driven interventions on QoL over 2 years in older adults with HNC. EGeSOR was a randomized study of HNC patients aged ≥65, receiving a pretreatment GA, a geriatric intervention and follow-up (intervention) or standard of care (control). The primary endpoint was QoL score using the European Organisation for Research and Treatment of Cancer’s (EORTC QLQ-C30) and HNC (QLQ-HN35) QoL questionnaires over 24 months. In total, 475 patients were included (median age: 75.3; women: 31%; oral cancer: 44%). QoL scores improved over 24 months with various trajectories, without significant differences between the groups. A total of 74% of patients (interventional group) did not receive the complete intervention. Cancer characteristics, functional status, and risk of frailty were associated with change in the Global Health Status QoL score. There is a need to develop an alternative model of implementation such as patient-centered health-care pathways. Trial registration NCT02025062.

Funder

French National Cancer Institute

Ligue Nationale contre le Cancer

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/jnci/article-pdf/116/5/758/57420880/djae027.pdf

Reference25 articles.

1. Patients with head and neck cancer: are they frailer than patients with other solid malignancies?;Bras;Eur J Cancer Care (Engl),2020

2. Impacts of geriatric evaluation and management programs on defined outcomes: overview of the evidence;Rubenstein;J Am Geriatr Soc,1991

3. Geriatric Assessment-Driven Intervention (GAIN) on chemotherapy-related toxic effects in older adults with cancer: a randomized clinical trial;Li;JAMA Oncol,2021

4. The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer: a randomised trial (GERICO);Lund;Br J Cancer,2021