Body mass index and molecular subtypes of colorectal cancer-Reference-Cited by-同舟云学术

Body mass index and molecular subtypes of colorectal cancer

Published:2022-11-29 Issue:2 Volume:115 Page:165-173
ISSN:0027-8874
Container-title:JNCI: Journal of the National Cancer Institute
language:en
Short-container-title:

Author:

Murphy Neil¹^ORCID,Newton Christina C²,Song Mingyang³⁴⁵⁶^ORCID,Papadimitriou Nikos¹,Hoffmeister Michael⁷^ORCID,Phipps Amanda I⁸,Harrison Tabitha A⁸^ORCID,Newcomb Polly A⁸,Aglago Elom K⁹,Berndt Sonja I¹⁰,Brenner Hermann⁷^ORCID,Buchanan Daniel D¹¹¹²¹³,Cao Yin¹⁴¹⁵¹⁶^ORCID,Chan Andrew T⁵⁶¹⁷,Chen Xuechen⁷¹⁸^ORCID,Cheng Iona¹⁹,Chang-Claude Jenny²⁰²¹,Dimou Niki¹,Drew David⁵⁶^ORCID,Farris Alton B²²,French Amy J²³,Gallinger Steven²⁴,Georgeson Peter¹¹¹²,Giannakis Marios²⁵²⁶,Giles Graham G²⁷²⁸²⁹,Gruber Stephen B³⁰,Harlid Sophia³¹^ORCID,Hsu Li⁸³²,Huang Wen-Yi¹⁰^ORCID,Jenkins Mark A²⁸,Laskar Ruhina S¹,Le Marchand Loic³³^ORCID,Limburg Paul³⁴,Lin Yi⁸,Mandic Marko⁷,Nowak Johnathan A³⁵,Obón-Santacana Mereia³⁶³⁷³⁸,Ogino Shuji³²⁵³⁵³⁹,Qu Conghui⁸,Sakoda Lori C⁸⁴⁰,Schoen Robert E⁴¹,Southey Melissa C⁴²²⁷²⁹,Stadler Zsofia K⁴³,Steinfelder Robert S⁸,Sun Wei⁸^ORCID,Thibodeau Stephen N³⁴,Toland Amanda E⁴⁴,Trinh Quang M⁴⁵,Tsilidis Kostas K⁹⁴⁶,Ugai Tomotaka³³⁵^ORCID,Van Guelpen Bethany³¹⁴⁷^ORCID,Wang Xiaoliang⁸^ORCID,Woods Michael O⁴⁸^ORCID,Zaidi Syed H⁴⁵,Gunter Marc J¹^ORCID,Peters Ulrike⁸⁴⁹,Campbell Peter T⁵⁰

Affiliation:

1. Nutrition and Metabolism Branch, International Agency for Research on Cancer , Lyon, France

2. Population Science Department, American Cancer Society (ACS) , Atlanta, GA, USA

3. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University , Boston, MA, USA

4. Department of Nutrition, Harvard T.H. Chan School of Public Health , Boston, MA, USA

5. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA

6. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School , Boston, MA, USA

7. Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ) , Heidelberg, Germany

8. Public Health Sciences Division, Fred Hutchinson Cancer Center , Seattle, WA, USA

9. Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health , London, UK

10. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA

11. Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne , Parkville, VIC, Australia

12. University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre , Melbourne, VIC, Australia

13. Genomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital , Parkville, VIC, Australia

14. Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine , St Louis, MO, USA

15. Division of Gastroenterology, Department of Medicine, Washington University School of Medicine , St Louis, MO, USA

16. Alvin J. Siteman Cancer Center , St Louis, MO, USA

17. Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School , Boston, MA, USA

18. Medical Faculty Heidelberg, Heidelberg University , Heidelberg, Germany

19. Department of Epidemiology and Biostatistics, University of California , San Francisco, San Francisco, CA, USA

20. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) , Heidelberg, Germany

21. Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf (UKE) , Hamburg, Germany

22. Department of Pathology, Emory University , Atlanta, GA, USA

23. Division of Laboratory Genetics, Department of Pathology and Laboratory Medicine, Mayo Clinic , Rochester, MN, USA

24. Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto , Toronto, ON, Canada

25. Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA, USA

26. Broad Institute of MIT and Harvard , Cambridge, MA, USA

27. Cancer Epidemiology Division, Cancer Council Victoria , Melbourne, VIC, Australia

28. Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne , Melbourne, VIC, Australia

29. Precision Medicine, School of Clinical Sciences at Monash Health, Monash University , Clayton, VIC, Australia

30. Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center , Duarte, CA, USA

31. Department of Radiation Sciences, Oncology Unit, Umeå University , Umeå, Sweden

32. Department of Biostatistics, University of Washington , Seattle, WA, USA

33. University of Hawaii Cancer Center, Epidemiology Program , Honolulu, HI, USA

34. Mayo Clinic , Rochester, MN, USA

35. Program in Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School , Boston, MA, USA

36. Unit of Biomarkers and Susceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat , Barcelona, Spain

37. ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat , Barcelona, Spain

38. Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) , Madrid, Spain

39. Department of Oncologic Pathology, Dana-Farber Cancer Institute , Boston, MA, USA

40. Division of Research, Kaiser Permanente Northern California , Oakland, CA, USA

41. Department of Medicine and Epidemiology, University of Pittsburgh Medical Center , Pittsburgh, PA, USA

42. Department of Clinical Pathology, The University of Melbourne , Melbourne, VIC, Australia

43. Department of Medicine, Memorial Sloan Kettering Cancer Center , New York, NY, USA

44. Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University , Columbus, OH, USA

45. Ontario Institute for Cancer Research , Toronto, ON, Canada

46. Department of Hygiene and Epidemiology, University of Ioannina School of Medicine , Ioannina, Greece

47. Wallenberg Centre for Molecular Medicine, Umeå University , Umeå, Sweden

48. Memorial University of Newfoundland, Discipline of Genetics , St. John's, NL, Canada

49. Department of Epidemiology, University of Washington , Seattle, WA, USA

50. Department of Epidemiology and Population Health, Albert Einstein College of Medicine , Bronx, NY, USA

Abstract

Abstract Background Obesity is an established risk factor for colorectal cancer (CRC), but the evidence for the association is inconsistent across molecular subtypes of the disease. Methods We pooled data on body mass index (BMI), tumor microsatellite instability status, CpG island methylator phenotype status, BRAF and KRAS mutations, and Jass classification types for 11 872 CRC cases and 11 013 controls from 11 observational studies. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for covariables. Results Higher BMI was associated with increased CRC risk (OR per 5 kg/m2 = 1.18, 95% CI = 1.15 to 1.22). The positive association was stronger for men than women but similar across tumor subtypes defined by individual molecular markers. In analyses by Jass type, higher BMI was associated with elevated CRC risk for types 1-4 cases but not for type 5 CRC cases (considered familial-like/Lynch syndrome microsatellite instability-H, CpG island methylator phenotype-low or negative, BRAF-wild type, KRAS-wild type, OR = 1.04, 95% CI = 0.90 to 1.20). This pattern of associations for BMI and Jass types was consistent by sex and design of contributing studies (cohort or case-control). Conclusions In contrast to previous reports with fewer study participants, we found limited evidence of heterogeneity for the association between BMI and CRC risk according to molecular subtype, suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The null association observed for the Jass type 5 suggests that BMI is not a risk factor for the development of CRC for individuals with Lynch syndrome.

Funder

Cancer Research UK

Spanish Association Against Cancer Scientific Foundation

National Cancer Institute

National Institutes of Health

U.S. Department of Health and Human Services

Center for Inherited Disease Research

NCI Cancer Center Support

Scientific Computing Infrastructure

Fred Hutch funded by Office of Research Infrastructure Program

Surveillance, Epidemiology and End Results

NIH