Remarkable response of BRAFV600E-mutated metastatic pancreatic cancer to BRAF/MEK inhibition: a case report-Reference-Cited by-同舟云学术

Remarkable response of BRAFV600E-mutated metastatic pancreatic cancer to BRAF/MEK inhibition: a case report

Published:2021-09-13 Issue: Volume: Page:
ISSN:2052-0034
Container-title:Gastroenterology Report
language:en
Short-container-title:

Author:

Li Hong-Shuai¹,Yang Ke²,Wang Yan¹

Affiliation:

1. Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P. R. China

2. Department of Medical Oncology, Cancer Hospital of HuanXing, Chaoyang District, Beijing, P. R. China

Funder

Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences

Chinese Society of Clinical Oncology (CSCO)-Hengrui Research Funding

Publisher

Oxford University Press (OUP)

Subject

Gastroenterology

Link

http://academic.oup.com/gastro/advance-article-pdf/doi/10.1093/gastro/goab031/40357593/goab031.pdf

Reference10 articles.

1. Mutations of the BRAF gene in human cancer;Davies;Nature,2002

2. Molecular landscape of pancreatic cancer: implications for current clinical trials;Heestand;Oncotarget,2015

3. KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling;Appleman;Mol Cancer Res,2012

4. Identification of targetable BRAF ΔN486_P490 variant by whole-genome sequencing leading to dabrafenib-induced remission of a BRAF-mutant pancreatic adenocarcinoma;Wrzeszczynski;Cold Spring Harb Mol Case Stud,2019

5. Successful BRAF/MEK inhibition in a patient with BRAF (V600E)-mutated extrapancreatic acinar cell carcinoma;Busch;Cold Spring Harb Mol Case Stud,2020

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