Affiliation:
1. School of Cardiovascular and Metabolic Medicine & Sciences and British Heart Foundation Centre of Research Excellence, King’s College London , London , UK
2. Department of Medical Sciences, University of Trieste , Italy
Abstract
Abstract
The progressive appreciation that multiple types of RNAs regulate virtually all aspects of tissue function and the availability of effective tools to deliver RNAs in vivo now offers unprecedented possibilities for obtaining RNA-based therapeutics. For the heart, RNA therapies can be developed that stimulate endogenous repair after cardiac damage. Applications in this area include acute cardioprotection after ischemia or cancer chemotherapy, therapeutic angiogenesis to promote new blood vessel formation, regeneration to form new cardiac mass, and editing of mutations to cure inherited cardiac disease. While the potential of RNA therapeutics for all these conditions is exciting, the field is still in its infancy. A number of roadblocks need to be overcome for RNA therapies to become effective, in particular, related to the problem of delivering RNA medicines into the cells and targeting them specifically to the heart.
Funder
European Research Council
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Developmental Biology,General Medicine
Reference73 articles.
1. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines;Heidenreich;Circulation.,2022
2. Long non-coding RNAs: definitions, functions, challenges and recommendations;Mattick;Nat Rev Mol Cell Biol.,2023
3. miRBase: from microRNA sequences to function;Kozomara;Nucleic Acids Res.,2019
4. Towards a complete map of the human long non-coding RNA transcriptome;Uszczynska-Ratajczak;Nat Rev Genet.,2018
5. Past, present, and future of circRNAs;Patop;EMBO J.,2019
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献