The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis

Author:

Svensson Elin M12,Svensson Robin J2,te Brake Lindsey H M1,Boeree Martin J3,Heinrich Norbert45,Konsten Sarah45,Churchyard Gavin678,Dawson Rodney9,Diacon Andreas H10,Kibiki Gibson S11,Minja Lilian T12,Ntingiya Nyanda E13,Sanne Ian14,Gillespie Stephen H15,Hoelscher Michael45,Phillips Patrick P J1617,Simonsson Ulrika S H2,Aarnoutse Rob1

Affiliation:

1. Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

2. Department of Pharmaceutical Biosciences, Uppsala University, Sweden

3. Department of Lung Diseases, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands

4. Medical Centre of the University of Munich (LMU), Munich Partner Site, Germany

5. German Center for Infection Research (DZIF), Munich Partner Site, Germany

6. The Aurum Institute, Johannesburg, South Africa

7. School of Public Health, University of Witwatersr, Johannesburg, South Africa

8. Advancing Treatment and Care for TB and HIV, South African Medical Research Council, Johannesburg, South Africa

9. University of Cape Town Lung Institute, Cape Town, South Africa

10. University of Stellenbosch, Cape Town, South Africa

11. Kilimanjaro Clinical Research Institute, Moshi

12. Ifakara Health Institute, Bagamoyo

13. NIMR-Mbeya Medical Research Centre, Mbeya, Tanzania

14. University of the Witswatersrand, Johannesburg, South Africa

15. University of St Andrews, United Kingdom

16. MRC Clinical Trials Unit, University College of London, United Kingdom

17. Division of Pulmonary and Critical Care Medicine, University of California San Francisco, US

Funder

European and Developing Countries Clinical Trials

German Ministry for Education and Research

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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