Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012

Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012–2013

Published:2018-02-20 Issue:3 Volume:67 Page:327-333
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Cobey Sarah¹,Gouma Sigrid²,Parkhouse Kaela²,Chambers Benjamin S²,Ertl Hildegund C³⁴,Schmader Kenneth E³⁴,Halpin Rebecca A⁵,Lin Xudong⁵,Stockwell Timothy B⁵,Das Suman R⁵,Landon Emily⁶,Tesic Vera⁷,Youngster Ilan⁸⁹,Pinsky Benjamin A¹⁰¹¹,Wentworth David E⁵,Hensley Scott E²,Grad Yonatan H¹²¹³

Affiliation:

1. Department of Ecology & Evolution, University of Chicago, Illinois

2. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia

3. Division of Geriatrics, Duke University Medical Center, North Carolina

4. Geriatric Research, Education, and Clinical Center, Durham VA Medical Center, North Carolina

5. Department of Infectious Disease, J. Craig Venter Institute, Rockville, Maryland

6. Department of Medicine, University of Chicago, Illinois

7. Department of Pathology, University of Chicago, Illinois

8. Division of Pediatrics and the Center for Microbiome Research, Assaf Harofeh Medical Center, Tel Aviv University, Israel

9. Division of Infectious Diseases, Boston Children’s Hospital, Massachusetts

10. Department of Pathology, Stanford University School of Medicine, California

11. Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, California

12. Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, Massachusetts

13. Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts

Funder

Burroughs Wellcome Fund

Doris Duke Charitable Foundation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

http://academic.oup.com/cid/article-pdf/67/3/327/25156319/ciy097.pdf

Reference43 articles.

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3. Effectiveness of seasonal influenza vaccine in community-dwelling elderly people: a meta-analysis of test-negative design case-control studies;Darvishian;Lancet Infect Dis,2014

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