Affiliation:
1. Laboratory of Clinical, Forensic and Environmental Toxicology, Center for Interdisciplinary Research on Medicines (CIRM), Central University Hospital of Liege, Liege 4000, Belgium
Abstract
Abstract
We describe herewith the case of a patient presenting to the emergency department for worsening ear–nose–throat symptoms. As chemsex was evocated by the family, patient’s serum was submitted to a new psychoactive substances screening. After a simple liquid–liquid extraction, serum was injected on a high-resolution mass spectrometer using quite usual conditions (C18 column, gradient mode with acidic buffer, methanol and acetonitrile). An almost perfect match with 2-aminoindane (2-AI) was observed considering that the precursor ion was present in the sample but absent in the commercial library. Literature concerning 2-AI is sparse, and further investigations were undertaken. After injection of the reference standard, a small retention time shift has been observed (0.3 min) between the standard and the sample. The case was only closed while spiking the sample with the standard, giving rise to two distinct peaks. As a result, 2-AI was then considered as absent from the sample and death was attributed only to infection. Moreover, a rapid liquid chromatography–tandem mass spectrometry method dedicated to 2-AI was developed. It generated the same false-positive result highlighted by significant differences observed in ion ratios (2.37 for the sample versus 6.62 for the neat standard).
Publisher
Oxford University Press (OUP)
Subject
Chemical Health and Safety,Health, Toxicology and Mutagenesis,Toxicology,Environmental Chemistry,Analytical Chemistry
Reference19 articles.
1. Fentanils and synthetic cannabinoids: driving greater complexity into the drug situation, European Monitoring Center for Drugs and Drug Addiction,2018
2. Aminoindanes – The next wave of ‘legal highs’;Sainsbury;Drug Testing and Analysis,2011
3. Pharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives;Simmler;Biochemical Pharmacology,2014
4. Erowid experience vaults. Erowid
5. Research chemicals forums. Psychoactif
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Ceftriaxone/clindamycin;Reactions Weekly;2022-06